ZFIN ID: ZDB-GENE-040822-21
Gene Name: matrilin 3a
Gene Symbol: matn3a    Nomenclature History

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Previous Names: ns:zf-e359, si:dkeyp-50f7.4, zgc:101120

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to be involved in growth plate cartilage chondrocyte morphogenesis. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Is expressed in notochord; skeletal system; and vertebra. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5; osteoarthritis; and osteochondrodysplasia. Orthologous to human MATN3 (matrilin 3).
Genome Resources: Alliance (1),  Gene:445503 (1),  Ensembl(GRCz11):ENSDARG00000069245 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 2 publications
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2004 [IMAGE:7148317]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb181 Insertion Unknown Unknown CRISPR
ihb196 Small Deletion Exon 3 Unknown CRISPR
ihb197 Small Deletion Exon 3 Unknown CRISPR
la021666Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45716 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-matn3a 1
    CRISPR2-matn3a 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH matn3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    multiple epiphyseal dysplasia 5 Alliance Epiphyseal dysplasia, multiple, 5 607078
    ?Spondyloepimetaphyseal dysplasia 608728
    {Osteoarthritis susceptibility 2} 140600
    DISEASE ASSOCIATED WITH matn3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component collagen-containing extracellular matrix (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA matn3a-201 (1)    Ensembl 1463
    matn3a-203 (1)    Ensembl 1954
    matn3a-204 (1)    Ensembl 1974
    matn3a-205 (1)    Ensembl 740
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-matn3a polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM matn3a No data available
    MARKER RELATIONSHIPS
    matn3a Contained in: [BAC] DKEYP-50F7 (1)
    matn3a Encodes: [EST] IMAGE:7148317 (1), zf-e359 (1)
    [cDNA] MGC:101120 (1), MGC:174732 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004007 (1) 1990 nt
    Genomic GenBank:BX942827 (1) 184704 nt
    Select Tool
    Polypeptide UniProtKB:F1QH95 (1) 460 aa
    Sequence Information (all 33)
    ORTHOLOGY for matn3a ( Chr: 20 )
    CITATIONS (34)