ZFIN ID: ZDB-GENE-040816-1
Gene Name: cadherin 5
Gene Symbol: cdh5
Sequence Ontology ID : SO:0000704

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Previous Names: cadherin 5, type 2, VE-cadherin (vascular epithelium), fc88a07, mlb, vascular endothelial cadherin (1), vecdn (1), wu:fc88a07 (1)

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have several functions, including cadherin binding activity, calcium ion binding activity, and cytoskeletal protein binding activity; involved in several processes, including circulatory  ...
GENE EXPRESSION
All Expression Data: 105 figures from 75 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bw306 Point Mutation Exon 3 Premature Stop ENU
hsi8 Complex Unknown Unknown CRISPR
sa7601 Point Mutation Unknown Missense ENU
sa10732 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21048 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21049 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34151 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38634 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40984 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ubs8 Small Deletion Exon 3 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    ubs9 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
    Targeting reagents:
    PHENOTYPE
    Data: 25 figures from 12 publications
    Observed in:
    DISEASE ASSOCIATED WITH cdh5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdh5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion involved in sprouting angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000233 (1)
  • InterPro:IPR002126 (1)
  • InterPro:IPR015919 (1)
  • InterPro:IPR020894 (1)
  • InterPro:IPR027397 (1)
  • InterPro:IPR030052 (1)
  • InterPro:IPR039808 (1)
  • PROSITE:PS00232 (1)
  • Pfam:PF00028 (1)
  • Pfam:PF01049 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cdh5-201 (1) 6772
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM cdh5
    MARKER RELATIONSHIPS
    cdh5Contained in: [Fosmid] CH1073-220I8 (1) (order this)
    cdh5Encodes: [EST] fc88a07
    [cDNA] MGC:194987 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003983 (1) 3102bp
    Genomic GenBank:CU464121 (1) 77238bp
    Select Tool
    Polypeptide UniProtKB:B3DJF6 (1) 767aa
    Sequence Clusters UniGene:118013 (1)
    Sequence Information (all 21)
    OTHER cdh5 GENE PAGES
  • Alliance (1)
  • Gene:445471 (1)
  • VEGA:OTTDARG00000042914 (1)
  • Ensembl(GRCz11):ENSDARG00000075549 (2)
  • ORTHOLOGY for cdh5 (Chr: 7)
    CITATIONS (178)