Gene

cdh5

ID
ZDB-GENE-040816-1
Name
cadherin 5
Symbol
cdh5 Nomenclature History
Previous Names
  • cadherin 5, type 2, VE-cadherin (vascular epithelium)
  • fc88a07
  • mlb
  • vascular endothelial cadherin (1)
  • vecdn (1)
  • wu:fc88a07 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have cadherin binding activity and calcium ion binding activity. Involved in circulatory system development; negative regulation of angiogenesis; and unidimensional cell growth. Predicted to localize to adherens junction; bicellular tight junction; and catenin complex. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; lateral mesoderm; and nervous system. Orthologous to human CDH5 (cadherin 5).
Genome Resources
Note
None
Expression
All Expression Data
111 figures from 80 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdh5 Human Ortholog
No data available
Associated With cdh5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, cytoplasmic domain
Domain IPR002126 Cadherin-like
Family IPR030052 VE-cadherin
Family IPR039808 Cadherin
Homologous_superfamily IPR015919 Cadherin-like superfamily
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Domain Details Per Protein
Protein Length Cadherin Cadherin conserved site Cadherin, cytoplasmic domain Cadherin-like Cadherin-like superfamily Catenin binding domain superfamily VE-cadherin
UniProtKB:Q68SP4 767
UniProtKB:B3DJF6 767
UniProtKB:F1R2I9 767
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdh5 Rabbit
  • IHC
  • WB
25
Ab2-cdh5 polyclonal Rabbit
  • WB
SDIX
1
Ab6-cdh5 polyclonal Rat
  • IHC
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations