ZFIN ID: ZDB-GENE-040808-73
Gene Name: NADH:ubiquinone oxidoreductase core subunit V1
Gene Symbol: ndufv1    Nomenclature History

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Previous Names: wu:fc01f01, wu:fc12f12, zgc:86620

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and coenzyme binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to localize to mitochondrial respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1).
Genome Resources: Alliance (1),  Gene:445291 (1),  Ensembl(GRCz11):ENSDARG00000036438 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6892746]
  6 figures (7 images) from Thisse et al., 2004 [IMAGE:7157113]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43227 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ndufv1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mitochondrial complex I deficiency, nuclear type 4 618225
    DISEASE ASSOCIATED WITH ndufv1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component membrane (more)
    Molecular Function 4 iron, 4 sulfur cluster binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ndufv1-201 (1)    Ensembl 1915
    ncRNA ndufv1-003 (1)    Ensembl 1310
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ndufv1 No data available
    MARKER RELATIONSHIPS
    ndufv1 Contained in: [BAC] CH211-130O18 (1)
    ndufv1 Encodes: [EST] fc01f01, fc12f12, IMAGE:6892746 (1), IMAGE:7157113 (1)
    [cDNA] MGC:86620 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003747 (1) 1951 nt
    Genomic GenBank:CR391915 (1) 77634 nt
    Select Tool
    Polypeptide UniProtKB:Q6AZA2 (1) 492 aa
    Sequence Information (all 13)
    ORTHOLOGY for ndufv1 ( Chr: 19 )
    CITATIONS (25)