Gene

ndufv1

ID
ZDB-GENE-040808-73
Name
NADH:ubiquinone oxidoreductase core subunit V1
Symbol
ndufv1 Nomenclature History
Previous Names
  • wu:fc01f01
  • wu:fc12f12
  • zgc:86620
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and nucleotide binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ndufv1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nuclear type mitochondrial complex I deficiency 4 Alliance Mitochondrial complex I deficiency, nuclear type 4 618225
Associated With ndufv1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Domain IPR011538 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Domain IPR019554 Soluble ligand binding domain
Domain IPR019575 NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Family IPR011537 NADH ubiquinone oxidoreductase, F subunit
Homologous_superfamily IPR037207 NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Homologous_superfamily IPR037225 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
Domain Details Per Protein
Protein Length NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily NADH ubiquinone oxidoreductase, F subunit Soluble ligand binding domain
UniProtKB:Q6AZA2 492
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations