ZFIN ID: ZDB-GENE-040808-44
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Gene Name: aldo-keto reductase family 1, member A1a (aldehyde reductase)
Gene Symbol: akr1a1a    Nomenclature History

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Previous Names: akr1a1, zgc:100940

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have alditol:NADP+ 1-oxidoreductase activity. Predicted to be involved in cellular detoxification of aldehyde. Predicted to localize to the apical plasma membrane and cytosol. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).
Genome Resources: Alliance (1),  Gene:445326 (1),  Ensembl(GRCz11):ENSDARG00000035257 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7146346]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH akr1a1a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH akr1a1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular detoxification of aldehyde (more)
Cellular Component apical plasma membrane (more)
Molecular Function NOT   retinol dehydrogenase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR018170 Aldo/keto reductase, conserved site
Family IPR020471 Aldo/keto reductase
Domain IPR023210 NADP-dependent oxidoreductase domain
Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA akr1a1a-201 (1)    Ensembl 1098
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Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM akr1a1a No data available
MARKER RELATIONSHIPS
akr1a1a Contained in: [BAC] CH211-113N10 (1), DKEY-165I4 (1) (order this)
akr1a1a Encodes: [EST] IMAGE:7146346 (1)
[cDNA] MGC:100940 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001003783 (1) 1120 bp
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Genomic GenBank:CR318632 (1) 143278 bp
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Polypeptide UniProtKB:A0A2U3TW59 (1) 324 aa
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Sequence Information (all 12)
ORTHOLOGY for akr1a1a ( Chr: 5 )
CITATIONS (20)