ZFIN ID: ZDB-GENE-040808-32
Gene Name: cholinergic receptor, nicotinic, epsilon
Gene Symbol: chrne
Previous Names: AChR epsilon (1), im:7154697, zgc:101010
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 5 figures (9 images) from Thisse et al., 2004 [IMAGE:7154697]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  adaxial cell, central nervous system, musculature system, polster (all 5) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-chrne (1)

Allele Type Mutagen Suppliers
sa15968 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: Fig. 10 from Mongeon et al., 2011
    Observed in: synaptic transmission, cholinergic
    DISEASE ASSOCIATED WITH chrne HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome Myasthenic syndrome, congenital, 4A, slow-channel 605809
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency 608931
    Myasthenic syndrome, congenital, 4B, fast-channel 616324
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process synaptic transmission, cholinergic (more)
    Cellular Component acetylcholine-gated channel complex (more)
    Molecular Function CONTRIBUTES_TO acetylcholine receptor activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002394 (1)
  • InterPro:IPR006029 (1)
  • InterPro:IPR006201 (1)
  • InterPro:IPR006202 (1)
  • InterPro:IPR018000 (1)
  • InterPro:IPR027361 (1)
  • PROSITE:PS00236 (1)
  • Pfam:PF02931 (1)
  • Pfam:PF02932 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA chrne-001 (1) 2557
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-chrne,chrng (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrne No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    chrne Contained in: [BAC] CH211-147A23 (1) (order this), DKEY-89J23 (1) (order this)
    chrne Encodes: [EST] IMAGE:7154697 (1) (order this)
    [cDNA] MGC:101010 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003772 (1) 1475 bp
    Genomic GenBank:BX324194 (1) 187691 bp
    Select Tool
    Polypeptide UniProtKB:A2BG85 (1) 517 aa
    Sequence Clusters UniGene:85037 (1)
    Sequence Information (all 17)
    OTHER chrne GENE PAGES
  • Gene:445315 (1)
  • VEGA:OTTDARG00000018422 (1)
  • Ensembl(Zv9):ENSDARG00000034307 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish chrne 5  
    Human CHRNE 17 (17p13.2)
  • OMIM:100725
  • Gene:1145
  • Mouse Chrne 11 ( 43.14 cM)
  • MGI:87894
  • Gene:11448
  • Orthology Details
    CITATIONS (19)