Gene

lhb

ID
ZDB-GENE-040806-2
Name
luteinizing hormone subunit beta
Symbol
lhb Nomenclature History
Previous Names
  • LHB
  • Gth II
  • gthII
  • LH Beta
  • zgc:92312
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits hormone activity. Involved in female gonad development; gamete generation; and sex determination. Predicted to localize to cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Is expressed in several structures, including endocrine system; female organism; kidney; liver; and male organism. Orthologous to several human genes including LHB (luteinizing hormone subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
42 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lhb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 23 with or without anosmia Alliance Hypogonadotropic hypogonadism 23 with or without anosmia 228300
Associated With lhb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018245 Gonadotropin, beta subunit, conserved site
Domain IPR006208 Glycoprotein hormone subunit beta
Family IPR001545 Gonadotropin, beta subunit
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Glycoprotein hormone subunit beta Gonadotropin, beta subunit Gonadotropin, beta subunit, conserved site
UniProtKB:Q6QMF9 86
UniProtKB:Q5UK78 140
UniProtKB:Q6TCF6 140
UniProtKB:H2A0A0 135
UniProtKB:Q6TCF5 140
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-lhb Rabbit
  • WB
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations