ZFIN ID: ZDB-GENE-040806-2
Gene Name: luteinizing hormone subunit beta
Gene Symbol: lhb    Nomenclature History

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Previous Names: LHB, Gth II, gthII, LH Beta, zgc:92312

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits hormone activity. Involved in female gonad development; gamete generation; and sex determination. Predicted to localize to the cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Is expressed in several structures, including endocrine system; female organism; kidney; liver; and male organism. Orthologous to several human genes including LHB (luteinizing hormone subunit beta).
Genome Resources: Alliance (1),  Gene:402917 (1),  Ensembl(GRCz11):ENSDARG00000099363 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb348 Small Deletion Unknown Unknown TALEN
ihb349 Small Deletion Exon 2 Unknown TALEN
sa30366 Point Mutation Unknown Premature Stop ENU
sa44382 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • umo2 Small Deletion Exon 2 Unknown TALEN
    zf592 Indel Exon 2 Frameshift TALEN
    zf594 Indel Exon 2 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lhb N/A 1
    MO2-lhb N/A 1
    MO3-lhb N/A 1
    TALEN1-lhb 1
    TALEN2-lhb 2
    TALEN3-lhb 1
    DISEASE ASSOCIATED WITH lhb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 23 with or without anosmia Alliance Hypogonadotropic hypogonadism 23 with or without anosmia 228300
    DISEASE ASSOCIATED WITH lhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process female gonad development (more)
    Cellular Component extracellular region (more)
    Molecular Function hormone activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001545 Gonadotropin, beta subunit
    Domain IPR006208 Glycoprotein hormone subunit beta
    Conserved_site IPR018245 Gonadotropin, beta subunit, conserved site
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lhb-201 (1)    Ensembl 1378
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lhb Rabbit WB 6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lhb No data available
    MARKER RELATIONSHIPS
    lhb Contained in: [Fosmid] CH1073-470L8 (1)
    lhb Encodes: [cDNA] MGC:92312 (1), MGC:193585 (1), MGC:193602 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205622 (1) 1371 bp
    Genomic GenBank:CU928134 (1) 33143 bp
    Select Tool
    Polypeptide UniProtKB:Q5UK78 (1) 140 aa
    Sequence Information (all 35)
    ORTHOLOGY for lhb ( Chr: 13 )
    CITATIONS (131)