Gene

stac3

ID
ZDB-GENE-040801-248
Name
SH3 and cysteine rich domain 3
Symbol
stac3 Nomenclature History
Previous Names
  • zgc:91949 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity. Involved in several processes, including T-tubule organization; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle tissue development. Predicted to localize to cytosol; extrinsic component of cytoplasmic side of plasma membrane; and voltage-gated calcium channel complex. Is expressed in adaxial cell; musculature system; and somite. Used to study Native American myopathy. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stac3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Native American myopathy Alliance Myopathy, congenital, Baily-Bloch 255995
Associated With stac3 Via Experimental Models
Human Disease Fish Conditions Citations
Native American myopathy stac3mi34/mi34 control Linsley et al., 2017
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR035736 Stac3, first SH3 domain
Family IPR039688 STAC1/2/3
Homologous_superfamily IPR036028 SH3-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase C-like, phorbol ester/diacylglycerol-binding domain SH3 domain SH3-like domain superfamily STAC1/2/3 Stac3, first SH3 domain
UniProtKB:A0A2R8Q8P0 332
UniProtKB:Q6DBR6 334
UniProtKB:A0A0R4IBQ8 207
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-stac3 polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations