ZFIN ID: ZDB-GENE-040801-234 |
Gene Name: | GDP-mannose pyrophosphorylase B | ||||||
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Gene Symbol: | gmppb Nomenclature History | ||||||
Previous Names: | cb1066 (1), fc79b10, wu:fc79b10, zgc:92026 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 22 Mapping Details/Browsers | ||||||
Description: | Predicted to have GTP binding activity and mannose-1-phosphate guanylyltransferase activity. Involved in muscle fiber development and protein glycosylation. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; and muscular dystrophy-dystroglycanopathy. Is expressed in several structures, including epidermis; hatching gland; pectoral fin musculature; periderm; and polster. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). | ||||||
Genome Resources: | Alliance (1), Gene:445097 (1), Ensembl(GRCz11):ENSDARG00000017658 (2) |
All Expression Data: | 9 figures from 3 publications |
Directly Submitted Expression Data: | 5 figures (8 images) from Thisse et al., 2001 [cb1066] |
Wild-type Stages, Structures: | Cleavage:2-cell (0.75h-1.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) |
Curated Microarray Expression: | GEO (1) |
Data: | 4 figures from Carss et al., 2013 |
Observed in: |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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autosomal recessive limb-girdle muscular dystrophy type 2T | Alliance | Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 14 | 615352 |
congenital muscular dystrophy-dystroglycanopathy A14 | Alliance | Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 14 | 615350 |
muscular dystrophy-dystroglycanopathy | Alliance | Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 14 | 615351 |
Ontology | GO Term |
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Biological Process | muscle fiber development (more) |
Cellular Component | cellular_component (more) |
Molecular Function | GTP binding (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
gmppb-201
(1)
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1873 |
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ncRNA |
gmppb-002
(1)
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780 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
gmppb Contained in: | [Fosmid] CH1073-91K2 (1) (order this) |
gmppb Contains: | [SSLP] z4682 |
gmppb Encodes: |
[EST]
cb1066 (1) (order this),
fc79b10
[cDNA] MGC:92026 (1) (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_001003491 (1) | 1870 bp |
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Genomic | GenBank:FP102519 (1) | 37082 bp | |
Polypeptide | UniProtKB:F1R683 (1) | 360 aa |
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Sequence Clusters | UniGene:105356 (1) |