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ZIRC
ZFIN ID: ZDB-GENE-040801-234
Gene Name: GDP-mannose pyrophosphorylase B
Gene Symbol: gmppb    Nomenclature History

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Previous Names: cb1066 (1), fc79b10, wu:fc79b10, zgc:92026

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have GTP binding activity and mannose-1-phosphate guanylyltransferase activity. Involved in muscle fiber development and protein glycosylation. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; and muscular dystrophy-dystroglycanopathy. Is expressed in several structures, including epidermis; hatching gland; pectoral fin musculature; periderm; and polster. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B).
Genome Resources: Alliance (1),  Gene:445097 (1),  Ensembl(GRCz11):ENSDARG00000017658 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2001 [cb1066]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gmppb N/A 1
DISEASE ASSOCIATED WITH gmppb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2T Alliance Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 14 615352
congenital muscular dystrophy-dystroglycanopathy A14 Alliance Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 14 615350
muscular dystrophy-dystroglycanopathy Alliance Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 14 615351
DISEASE ASSOCIATED WITH gmppb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process muscle fiber development (more)
Cellular Component cellular_component (more)
Molecular Function GTP binding (more)
GO Terms (all 10)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gmppb-201 (1)    Ensembl 1873
ncRNA gmppb-002 (1)    Ensembl 780
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gmppb No data available
MARKER RELATIONSHIPS
gmppb Contained in: [Fosmid] CH1073-91K2 (1) (order this)
gmppb Contains: [SSLP] z4682
gmppb Encodes: [EST] cb1066 (1) (order this), fc79b10
[cDNA] MGC:92026 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001003491 (1) 1870 bp
Genomic GenBank:FP102519 (1) 37082 bp
Select Tool
Polypeptide UniProtKB:F1R683 (1) 360 aa
Sequence Clusters UniGene:105356 (1)
Sequence Information (all 28)
ORTHOLOGY for gmppb ( Chr: 22 )
CITATIONS (24)