Community Action Needed: Please respond to the NIH RFI
Gene

socs1a

ID
ZDB-GENE-040801-205
Name
suppressor of cytokine signaling 1a
Symbol
socs1a Nomenclature History
Previous Names
  • socs1 (1)
  • zgc:91868
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within several processes, including positive regulation of T cell migration; regulation of signal transduction; and regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including brain; digestive system; musculature system; pleuroperitoneal region; and visual system. Used to study fatty liver disease and hyperinsulinism. Human ortholog(s) of this gene implicated in ovarian carcinoma; prostate cancer; and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With socs1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Autoinflammatory syndrome, familial, with or without immunodeficiency 619375
Associated With socs1a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR001496 SOCS box domain
Domain IPR035861 SOCS1, SH2 domain
Family IPR028411 Suppressor of cytokine signalling 1
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length SH2 domain SH2 domain superfamily SOCS1, SH2 domain SOCS box domain Suppressor of cytokine signalling 1
UniProtKB:Q6DEF9 201
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-socs1a polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations