Gene

aurka

ID
ZDB-GENE-040801-161
Name
aurora kinase A
Symbol
aurka Nomenclature History
Previous Names
  • fb37c10
  • fc02c02
  • wu:fb37c10
  • wu:fc02c02
  • zgc:100912
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have histone serine kinase activity. Involved in mitotic cell cycle. Predicted to localize to microtubule cytoskeleton. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Jeon et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aurka Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance {Colon cancer, susceptibility to} 114500
Associated With aurka Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR030611 Aurora kinase A
Family IPR030616 Aurora kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Aurora kinase Aurora kinase A Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:F1QEM3 405
UniProtKB:F8W4T4 289
UniProtKB:Q6DBZ4 405
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-aurka polyclonal Mouse
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations