ZFIN Gene: srek1

ZFIN ID: ZDB-GENE-040801-132

ZFIN ID: ZDB-GENE-040801-132

Gene Name:

splicing regulatory glutamine/lysine-rich protein 1

Gene Symbol:

srek1 Nomenclature History

Previous Name:

zgc:100974 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 5 Mapping Details/Browsers

Description:

Predicted to have RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to nucleoplasm. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1).

Genome Resources:

Alliance (1), Gene:445219 (1), Ensembl(GRCz11):ENSDARG00000009764 (1)

GENE EXPRESSION
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148031]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	unspecified
High Throughput Expression:	Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la029126Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa6064	Point Mutation	Unknown	Splice Site	ENU
sa13077	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20535	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40563	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH srek1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH srek1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of alternative mRNA splicing, via spliceosome (more)
Cellular Component	nucleoplasm (more)
Molecular Function	nucleic acid binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	srek1-201 (1)	1879	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM srek1 No data available

MARKER RELATIONSHIPS

srek1 Contained in:	[BAC] CH211-10H13 (1)
srek1 Encodes:	[EST] IMAGE:7148031 (1) [cDNA] MGC:100974 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001003613 (1)	1990 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX950207 (1)	129862 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A2BIN4 (1)	515 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 26)

ORTHOLOGY for srek1 ( Chr: 5 )

CITATIONS (23)

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