ZFIN ID: ZDB-GENE-040724-26
Gene Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a
Gene Symbol: cacna1aa    Nomenclature History

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Previous Names: cacna1a (1), si:ch211-237k17.1, ZfCav2.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have voltage-gated calcium channel activity. Predicted to be involved in calcium ion import and chemical synaptic transmission. Predicted to localize to voltage-gated calcium channel complex. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A).
Genome Resources: Alliance (1),  Gene:562059 (1),  Ensembl(GRCz11):ENSDARG00000037905 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cacna1aa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 42 Alliance Epileptic encephalopathy, early infantile, 42 617106
episodic ataxia type 2 Alliance Episodic ataxia, type 2 108500
familial hemiplegic migraine 1 Alliance Migraine, familial hemiplegic, 1 141500
Migraine, familial hemiplegic, 1, with progressive cerebellar ataxia 141500
spinocerebellar ataxia type 6 Alliance Spinocerebellar ataxia 6 183086
DISEASE ASSOCIATED WITH cacna1aa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process calcium ion transmembrane transport (more)
Cellular Component integral component of membrane (more)
Molecular Function calcium channel activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cacna1aa-202 (1)    Ensembl 5851
cacna1aa-203 (1)    Ensembl 5848
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cacna1aa No data available
MARKER RELATIONSHIPS
cacna1aa Contained in: [BAC] CH211-237K17, DKEY-3F22 (1) (order this)
cacna1aa Encodes: [EST] eu1553 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005164090 (1) 6731 nt
Genomic GenBank:BX548009 (1) 128639 nt
Select Tool
Polypeptide UniProtKB:E9QJF6 (1) 2265 aa
Sequence Information (all 69)
ORTHOLOGY for cacna1aa ( Chr: 3 )
CITATIONS (31)