ZFIN ID: ZDB-GENE-040724-230
Gene Name: glyoxylate reductase/hydroxypyruvate reductase a
Gene Symbol: grhpra    Nomenclature History

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Previous Names: grhpr, si:ch211-240l14.3, zgc:109900

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; and hydroxypyruvate reductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase).
Genome Resources: Alliance (1),  Gene:497183 (1),  Ensembl(GRCz11):ENSDARG00000068264 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7152758]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22536 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH grhpra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary hyperoxaluria type 2 Alliance Hyperoxaluria, primary, type II 260000
    DISEASE ASSOCIATED WITH grhpra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component cytosol (more)
    Molecular Function NAD binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grhpra-201 (1)    Ensembl 1413
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grhpra No data available
    MARKER RELATIONSHIPS
    grhpra Contained in: [BAC] CH211-240L14, DKEY-109L4 (1) (order this)
    grhpra Encodes: [EST] IMAGE:7152758 (1)
    [cDNA] MGC:109900 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020525 (1) 1380 nt
    Genomic GenBank:CT573279 (1) 264426 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q504F9 (1) 327 aa
    Sequence Information (all 12)
    ORTHOLOGY for grhpra ( Chr: 14 )
    CITATIONS (20)