Gene

grhpra

ID
ZDB-GENE-040724-230
Name
glyoxylate reductase/hydroxypyruvate reductase a
Symbol
grhpra Nomenclature History
Previous Names
  • grhpr
  • si:ch211-240l14.3
  • zgc:109900
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have glycerate dehydrogenase activity; glyoxylate reductase (NADP+) activity; and hydroxypyruvate reductase activity. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grhpra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary hyperoxaluria type 2 Alliance Hyperoxaluria, primary, type II 260000
Associated With grhpra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site NAD(P)-binding domain superfamily
UniProtKB:Q504F9 327
UniProtKB:Q7SZY8 327
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations