ZFIN ID: ZDB-GENE-040724-208
Gene Name: transforming growth factor, alpha
Gene Symbol: tgfa    Nomenclature History

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Previous Name: si:ch211-10e8.7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have epidermal growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; and positive regulation of protein kinase activity. Predicted to localize to extracellular space. Is expressed in midbrain; retina; and third ventricle. Human ortholog(s) of this gene implicated in gastroenteritis and pancreatic cancer. Orthologous to human TGFA (transforming growth factor alpha).
Genome Resources: Alliance (1),  Gene:100034402 (1),  Ensembl(GRCz11):ENSDARG00000053939 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct816 Small Deletion Unknown Unknown TALEN
ct868 Small Deletion Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
TALEN1-tgfa 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tgfa HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tgfa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process activation of MAPK activity (more)
Cellular Component integral component of membrane (more)
Molecular Function epidermal growth factor receptor binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tgfa-202 (1)    Ensembl 3007
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tgfa
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
tg(hsp70l:tgfa) hsp70l tgfa Danio rerio 1 2
MARKER RELATIONSHIPS
tgfa Contained in: [BAC] CH211-10E8, CH211-13J1 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001144052 (1) 576 nt
Genomic GenBank:CR293534 (1) 109426 nt
Select Tool
Polypeptide UniProtKB:Q7T011 (1) 191 aa
Sequence Information (all 18)
ORTHOLOGY for tgfa ( Chr: 6 )
CITATIONS (26)