Gene

s100b

ID
ZDB-GENE-040718-290
Name
S100 calcium binding protein, beta (neural)
Symbol
s100b Nomenclature History
Previous Names
  • si:dkey-110p14.2
  • wu:fq18b10
  • zgc:92776
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have several functions, including RAGE receptor binding activity; S100 protein binding activity; and calcium-dependent protein binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of cell population proliferation. Predicted to localize to cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including digestive system; heart; integument; nervous system; and renal system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With s100b Human Ortholog
No data available
Associated With s100b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001751 S100/Calbindin-D9k, conserved site
Domain IPR002048 EF-hand domain
Domain IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
Family IPR028481 Protein S100-B
Family IPR028496 Protein S100-A4
Homologous_superfamily IPR011992 EF-hand domain pair
Domain Details Per Protein
Protein Length EF-hand domain EF-hand domain pair Protein S100-A4 Protein S100-B S100/CaBP-9k-type, calcium binding, subdomain S100/Calbindin-D9k, conserved site
UniProtKB:Q6DGT8 95
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-s100 polyclonal Rabbit
  • IHC
  • WB
Dako North America, Inc.
69
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations