ZFIN Gene: otub1a

ZFIN ID: ZDB-GENE-040718-108

ZFIN ID: ZDB-GENE-040718-108

Gene Name:

OTU deubiquitinase, ubiquitin aldehyde binding 1a

Gene Symbol:

otub1a Nomenclature History

Previous Names:

otub1l, fb17f04 (1), wu:fb17f04 (1), zgc:92685

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have NEDD8-specific protease activity; thiol-dependent ubiquitin-specific protease activity; and ubiquitin binding activity. Predicted to be involved in negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; and protein K48-linked deubiquitination. Predicted to localize to nucleus. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1).

Genome Resources:

Alliance (1), Gene:436684 (1), Ensembl(GRCz11):ENSDARG00000055536 (2)

GENE EXPRESSION
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:92685]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la014051Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa5960	Point Mutation	Unknown	Premature Stop	ENU

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-otub1a	N/A	2

PHENOTYPE

Data:	Fig. S4 from Tse et al., 2009
Observed in:	central nervous system extension post-vent region somite trunk whole organism

DISEASE ASSOCIATED WITH otub1a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH otub1a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	protein deubiquitination (more)
Cellular Component	nucleus (more)
Molecular Function	cysteine-type peptidase activity (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	otub1a-201 (1)	1169	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	otub1a-204 (1)	792	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	otub1a-002 (1)	532	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	otub1a-003 (1)	566	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	otub1a-005 (1)	517	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM otub1a No data available

MARKER RELATIONSHIPS

otub1a Contained in:	[BAC] DKEY-270M17 (1) (order this)
otub1a Encodes:	[EST] fb17f04, IMAGE:7144196 (1) [cDNA] MGC:92685 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001002411 (1)	1204 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR749775 (1)	71543 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6DH16 (1)	267 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 11)

ORTHOLOGY for otub1a ( Chr: 21 )

CITATIONS (30)

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