ZFIN Gene: cga

ZFIN ID: ZDB-GENE-040715-2

ZFIN ID: ZDB-GENE-040715-2

Gene Name:

glycoprotein hormones, alpha polypeptide

Gene Symbol:

cga Nomenclature History

Previous Names:

gonadotropin alpha subunit, GPHa, gsu-alpha (1), GTH-alpha

Gene Type:

protein_coding_gene

Location:

Chr: 17 Mapping Details/Browsers

Description:

Predicted to have follicle-stimulating hormone activity. Predicted to be involved in positive regulation of steroid biosynthetic process and thyroid hormone generation. Predicted to localize to extracellular space and follicle-stimulating hormone complex. Is expressed in adenohypophyseal placode; gill; hypophysis; and pleuroperitoneal region. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide).

Genome Resources:

Alliance (1), Gene:402987 (1), Ensembl(GRCz11):ENSDARG00000040479 (2)

GENE EXPRESSION
All Expression Data:	22 figures from 14 publications
Wild-type Stages, Structures:	Pharyngula:Prim-15 (30.0h-36.0h) to Adult (90d-730d, breeding adult)
	adenohypophyseal placode adenohypophysis follicle stimulating hormone secreting cell gill hypophysis kidney luteinizing hormone secreting cell ovary pars anterior proximal pars anterior thyroid stimulating hormone secreting cell unspecified whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-cga	N/A	1

PHENOTYPE

Data:	Fig. 5 from Huang et al., 2008
Observed in:	cardiac ventricle caudal fin head multicellular organism growth post-anal tail morphogenesis trunk whole organism

DISEASE ASSOCIATED WITH cga HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH cga VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	positive regulation of steroid biosynthetic process (more)
Cellular Component	extracellular region (more)
Molecular Function	hormone activity (more)

GO Terms (all 7)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	cga-202 (1)	1793	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM cga

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(cga:EGFP)	cga	EGFP	Danio rerio	1	2

MARKER RELATIONSHIPS

cga Contained in:	[BAC] CH73-73N15 (1)
cga Encodes:	[cDNA] MGC:136679 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_205687 (1)	1802 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU896650 (1)	93026 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6QX43 (1)	117 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 18)

ORTHOLOGY for cga ( Chr: 17 )

CITATIONS (46)

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