ZFIN ID: ZDB-GENE-040702-7
Gene Name: cannabinoid receptor 2
Gene Symbol: cnr2    Nomenclature History

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Previous Names: cb2a (1), cb2b (1), CB2R (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have cannabinoid receptor activity. Involved in several processes, including hematopoietic stem cell differentiation; hematopoietic stem cell migration to bone marrow; and liver development. Predicted to localize to cytoplasm and plasma membrane. Is expressed in several structures, including digestive system; gill; heart; hematopoietic system; and nervous system. Used to study anxiety disorder. Orthologous to human CNR2 (cannabinoid receptor 2).
Genome Resources: Alliance (1),  Gene:795246 (1),  Ensembl(GRCz11):ENSDARG00000039970 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36197 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • upr1 Small Deletion Unknown Unknown CRISPR
    zf426 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    zf427 Small Deletion Exon 2 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    zf680 Small Deletion Exon 1 Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cnr2 1
    MO1-cnr2 N/A 1
    MO2-cnr2 N/A 2
    MO3-cnr2 N/A 1
    TALEN1-cnr2 1
    DISEASE ASSOCIATED WITH cnr2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cnr2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    anxiety disorder cnr2upr1/upr1 standard conditions Acevedo-Canabal et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell migration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cannabinoid receptor activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cnr2-201 (1)    Ensembl 1379
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cnr2 No data available
    MARKER RELATIONSHIPS
    cnr2 Contained in: [BAC] DKEY-66C10 (1) (order this)
    cnr2 Encodes: [cDNA] MGC:194707 (1), MGC:194735 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212964 (1) 1228 nt
    Genomic RefSeq:NW_018394965 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:F1R8K4 (1) 383 aa
    Sequence Information (all 21)
    ORTHOLOGY for cnr2 ( Chr: 16 )
    CITATIONS (34)