Community Action Needed: Please respond to the NIH RFI
Gene

nlk1

ID
ZDB-GENE-040701-1
Name
nemo-like kinase, type 1
Symbol
nlk1 Nomenclature History
Previous Names
  • nlk
  • nlkb
  • zgc:111875
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable MAP kinase activity. Acts upstream of or within negative regulation of Notch signaling pathway; positive regulation of Wnt signaling pathway; and positive regulation of neurogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including eye; immature eye; neural plate; notochord; and otic vesicle. Orthologous to human NLK (nemo like kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ishitani et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nlk1 Human Ortholog
No data available
Associated With nlk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Mitogen-activated protein (MAP) kinase, conserved site Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q6Q382 475
UniProtKB:X1WHK9 384
UniProtKB:Q567M5 329
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations