Gene

pou1f1

ID
ZDB-GENE-040630-7
Name
POU class 1 homeobox 1
Symbol
pou1f1 Nomenclature History
Previous Names
  • pit-1 (1)
  • Pit1 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in cell fate specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Is expressed in adenohypophyseal placode; adenohypophysis; brain; and hypophysis. Orthologous to human POU1F1 (POU class 1 homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pou1f1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined or isolated, 1 613038
Associated With pou1f1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR000327 POU-specific domain
Domain IPR001356 Homeobox domain
Domain IPR013847 POU domain
Family IPR015586 Pituitary-specific positive transcription factor 1
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR010982 Lambda repressor-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Lambda repressor-like, DNA-binding domain superfamily Pituitary-specific positive transcription factor 1 POU domain POU-specific domain
UniProtKB:Q6TGI3 150
UniProtKB:A0A2R8RYW1 350
UniProtKB:Q6TGI2 141
UniProtKB:Q6TGI4 350
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations