Gene

ren

ID
ZDB-GENE-040630-3
Name
renin
Symbol
ren Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy; hypertension; and portal hypertension. Is expressed in intermediate mesoderm; interrenal primordium; and kidney. Orthologous to human REN (renin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ren Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial juvenile hyperuricemic nephropathy Alliance Tubulointerstitial kidney disease, autosomal dominant, 4 613092
Renal tubular dysgenesis 267430
[Hyperproreninemia]
Associated With ren Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001969 Aspartic peptidase, active site
Domain IPR033121 Peptidase family A1 domain
Domain IPR034135 Renin-like domain
Family IPR001461 Aspartic peptidase A1 family
Homologous_superfamily IPR021109 Aspartic peptidase domain superfamily
Domain Details Per Protein
Protein Length Aspartic peptidase A1 family Aspartic peptidase, active site Aspartic peptidase domain superfamily Peptidase family A1 domain Renin-like domain
UniProtKB:Q6XQJ0 395
UniProtKB:Q6YA65 395
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations