Gene
ren
- ID
- ZDB-GENE-040630-3
- Name
- renin
- Symbol
- ren Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy; hypertension; and portal hypertension. Is expressed in intermediate mesoderm; interrenal primordium; and kidney. Orthologous to human REN (renin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial juvenile hyperuricemic nephropathy | Alliance | Tubulointerstitial kidney disease, autosomal dominant, 4 | 613092 |
| Renal tubular dysgenesis | 267430 | ||
| [Hyperproreninemia] |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aspartic peptidase A1 | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Peptidase family A1 domain | Renin-like domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6YA65
|
395 |
Interactions and Pathways
No data available
Plasmids
No data available