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ZIRC
ZFIN ID: ZDB-GENE-040629-1
Gene Name: interferon gamma 1
Gene Symbol: ifng1    Nomenclature History

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Previous Names: ifng1-2, Ifng2 (1), ifng, Ifngamma2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have interferon-gamma receptor binding activity. Involved in several processes, including defense response to bacterium; endothelial to hematopoietic transition; and response to virus. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; ataxia telangiectasia; autoimmune hypersensitivity disease (multiple); bone disease (multiple); and leukemia (multiple). Is expressed in axial vasculature; blood; liver; and pleuroperitoneal region. Orthologous to human IFNG (interferon gamma).
Genome Resources: Alliance (1),  Gene:405790 (1),  Ensembl(GRCz11):ENSDARG00000024211 (1)
GENE EXPRESSION
All Expression Data: 40 figures from 27 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu773]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ifng1
1
CRISPR2-ifng1
1
CRISPR3-ifng1
1
MO1-ifng1 N/A 5
DISEASE ASSOCIATED WITH ifng1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aplastic anemia Alliance {Aplastic anemia} 609135
tuberous sclerosis 2 Alliance {TSC2 angiomyolipomas, renal, modifier of} 613254
{AIDS, rapid progression to} 609423
{Hepatitis C virus, response to therapy of} 609532
{Tuberculosis, protection against} 607948
DISEASE ASSOCIATED WITH ifng1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process defense response to bacterium (more)
Cellular Component extracellular region (more)
Molecular Function interferon-gamma receptor binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002069 (1)
  • InterPro:IPR009079 (1)
  • Pfam:PF00714 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ifng1-201 (1)    Ensembl 570
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ifng1-2 monoclonal WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ifng1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:ifng1-2-V5,cryaa:Cerulean) cryaahsp70l Ceruleanifng1V5 Danio rerio 1 2
    MARKER RELATIONSHIPS
    ifng1 Contained in: [BAC] CH211-266A5 (1) (order this)
    ifng1 Encodes: [EST] eu773 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212864 (1) 570 bp
    Genomic GenBank:BX465210 (1) 171708 bp
    Select Tool
    Polypeptide UniProtKB:Q75S22 (1) 185 aa
    Sequence Clusters UniGene:90633 (1)
    Sequence Information (all 13)
    ORTHOLOGY for ifng1 ( Chr: 4 )
    CITATIONS (128)