Gene

irx5b

ID
ZDB-GENE-040628-5
Name
iroquois homeobox 5b
Symbol
irx5b Nomenclature History
Previous Names
  • iro5b (1)
  • ziro5b (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in cell development; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; pectoral fin bud; pronephric duct; statoacoustic (VIII) ganglion; and trigeminal placode. Orthologous to human IRX5 (iroquois homeobox 5).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irx5b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hamamy syndrome 611174
Associated With irx5b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003893 Iroquois-class homeodomain protein
Domain IPR008422 Homeobox KN domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox KN domain Homeobox-like domain superfamily Iroquois-class homeodomain protein
UniProtKB:B3DH47 371
UniProtKB:B1H1L6 371
UniProtKB:Q6R5L3 371
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations