ZFIN is now using GRCz12tu for Genomic Data
Gene
eif2b1
- ID
- ZDB-GENE-040625-25
- Name
- eukaryotic translation initiation factor 2B, subunit 1 alpha
- Symbol
- eif2b1 Nomenclature History
- Previous Names
-
- zgc:86660
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894278 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 1 | Alliance | Leukoencephalopathy with vanishing white matter 1, with or without ovarian failure | 603896 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000649 | Initiation factor 2B-related |
| Family | IPR051501 | Eukaryotic initiation factor 2B subunits alpha/beta/delta |
| Homologous_superfamily | IPR037171 | NagB/RpiA transferase-like |
| Homologous_superfamily | IPR042528 | Translation initiation factor eIF-2B subunit alpha, N-terminal |
| Homologous_superfamily | IPR042529 | Initiation factor 2B-like, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | Eukaryotic initiation factor 2B subunits alpha/beta/delta | Initiation factor 2B-like, C-terminal | Initiation factor 2B-related | NagB/RpiA transferase-like | Translation initiation factor eIF-2B subunit alpha, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4ILD9 | InterPro | 302 | |||||
| UniProtKB:Q6IQQ8 | InterPro | 291 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2b1-201
(1)
|
Ensembl | 1,218 nt | ||
| mRNA |
eif2b1-202
(1)
|
Ensembl | 1,223 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers