ZFIN ID: ZDB-GENE-040625-25
Gene Name: eukaryotic translation initiation factor 2B, subunit 1 alpha
Gene Symbol: eif2b1    Nomenclature History

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Previous Name: zgc:86660

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in regulation of translational initiation and translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).
Genome Resources: Alliance (1),  Gene:415150 (1),  Ensembl(GRCz11):ENSDARG00000091402 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 3 figures (6 images) from Thisse et al., 2004 [IMAGE:6894278]
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12357 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40609 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif2b1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    leukoencephalopathy with vanishing white matter Alliance Leukoencephalopathy with vanishing white matter 603896
    DISEASE ASSOCIATED WITH eif2b1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular metabolic process (more)
    Cellular Component eukaryotic translation initiation factor 2B complex (more)
    Molecular Function translation initiation factor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif2b1-201 (1)    Ensembl 1218
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif2b1 No data available
    MARKER RELATIONSHIPS
    eif2b1 Contained in: [BAC] CH211-157P22 (1), DKEY-204G14 (1) (order this)
    eif2b1 Encodes: [EST] IMAGE:6894278 (1)
    [cDNA] MGC:86660 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002060 (1) 1176 nt
    Genomic GenBank:CT978957 (1) 164556 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ILD9 (1) 302 aa
    Sequence Information (all 15)
    ORTHOLOGY for eif2b1 ( Chr: 5 )
    CITATIONS (19)