ZFIN ID: ZDB-GENE-040625-24
Gene Name: lumican
Gene Symbol: lum    Nomenclature History

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Previous Names: lumican (1), zgc:86661 (1), zlum (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Involved in collagen fibril organization and embryonic camera-type eye morphogenesis. Predicted to localize to the collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic cancer. Is expressed in several structures, including digestive system; epidermis; head mesenchyme; heart; and nervous system. Orthologous to human LUM (lumican).
Genome Resources: Alliance (1),  Gene:415149 (1),  Ensembl(GRCz11):ENSDARG00000045580 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-lum N/A 1
DISEASE ASSOCIATED WITH lum HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH lum VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process collagen fibril organization (more)
Cellular Component collagen-containing extracellular matrix (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000372 Leucine-rich repeat N-terminal domain
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Family IPR027219 Lumican
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lum-201 (1)    Ensembl 1805
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-lum polyclonal Rabbit IHC, WB 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lum No data available
MARKER RELATIONSHIPS
lum Contained in: [BAC] DKEYP-38G8 (1)
lum Encodes: [EST] IMAGE:6904895 (1), IMAGE:7145913 (1)
[cDNA] MGC:86661 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001002059 (1) 2030 bp
Genomic GenBank:BX322608 (1) 161099 bp
Select Tool
Polypeptide UniProtKB:F1R6G3 (1) 372 aa
Sequence Information (all 17)
ORTHOLOGY for lum ( Chr: 4 )
CITATIONS (24)