Gene

tcf12

ID
ZDB-GENE-040516-11
Name
transcription factor 12
Symbol
tcf12 Nomenclature History
Previous Names
  • TF12 (1)
  • wu:fb74g05
  • wu:fc43e06
  • zgc:110341
  • zgc:85956
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in craniosynostosis. Is expressed in several structures, including central nervous system; cranial vault; mesoderm; neural tube; and presumptive diencephalon. Orthologous to human TCF12 (transcription factor 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Davis et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcf12 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniosynostosis Alliance Craniosynostosis 3 615314
Associated With tcf12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations