ZFIN ID: ZDB-GENE-040426-938
Gene Name: BC1 (ubiquinol-cytochrome c reductase) synthesis-like
Gene Symbol: bcs1l    Nomenclature History

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Previous Name: zgc:56205 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have ATP binding activity. Predicted to be involved in mitochondrial respiratory chain complex III assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Bjornstad syndrome; GRACILE syndrome; Leigh disease; and mitochondrial complex III deficiency nuclear type 1. Orthologous to human BCS1L (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone).
Genome Resources: Alliance (1),  Gene:394157 (1),  Ensembl(GRCz11):ENSDARG00000012295 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-bcs1l N/A 1
TALEN1-bcs1l
1
DISEASE ASSOCIATED WITH bcs1l HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bjornstad syndrome Alliance Bjornstad syndrome 262000
GRACILE syndrome Alliance GRACILE syndrome 603358
Leigh disease Alliance Leigh syndrome 256000
mitochondrial complex III deficiency nuclear type 1 Alliance Mitochondrial complex III deficiency, nuclear type 1 124000
DISEASE ASSOCIATED WITH bcs1l VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process mitochondrial respiratory chain complex III assembly (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA bcs1l-201 (1)    Ensembl 1694
bcs1l-202 (1)    Ensembl 795
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM bcs1l No data available
MARKER RELATIONSHIPS
bcs1l Contained in: [BAC] DKEYP-68F9 (1)
bcs1l Encodes: [cDNA] MGC:56205 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201182 (1) 1698 nt
Genomic GenBank:BX001051 (1) 213486 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q7ZV60 (1) 420 aa
Sequence Information (all 12)
ORTHOLOGY for bcs1l ( Chr: 9 )
CITATIONS (25)