ZFIN ID: ZDB-GENE-040426-929
Gene Name: peroxisomal biogenesis factor 12
Gene Symbol: pex12    Nomenclature History

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Previous Name: zgc:56182

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ubiquitin-protein transferase activity. Predicted to be involved in protein import into peroxisome matrix and protein monoubiquitination. Predicted to localize to the integral component of peroxisomal membrane and peroxisomal importomer complex. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 3A. Orthologous to human PEX12 (peroxisomal biogenesis factor 12).
Genome Resources: Alliance (1),  Gene:393174 (1),  Ensembl(GRCz11):ENSDARG00000035149 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pex12 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
infantile Refsum disease Alliance Peroxisome biogenesis disorder 3B 266510
peroxisome biogenesis disorder 3A Alliance Peroxisome biogenesis disorder 3A (Zellweger) 614859
Refsum disease Alliance Peroxisome biogenesis disorder 3B 266510
DISEASE ASSOCIATED WITH pex12 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process protein targeting to peroxisome (more)
Cellular Component integral component of membrane (more)
Molecular Function protein C-terminus binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR006845 Pex, N-terminal
Family IPR017375 Peroxisome assembly protein 12
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pex12-201 (1)    Ensembl 1406
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pex12 No data available
MARKER RELATIONSHIPS
pex12 Contained in: [BAC] DKEY-261J4 (1) (order this)
pex12 Encodes: [cDNA] MGC:56182 (1), MGC:191427 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200205 (1) 1413 nt
Genomic GenBank:AL935280 (1) 221563 nt Blast at MegaBLAST
Polypeptide UniProtKB:B0R157 (1) 350 aa
Sequence Information (all 19)
ORTHOLOGY for pex12 ( Chr: 5 )
CITATIONS (19)