ZFIN ID: ZDB-GENE-040426-918
Gene Name: LIM domain containing preferred translocation partner in lipoma
Gene Symbol: lpp    Nomenclature History

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Previous Names: fc26e09, wu:fc26e09, zgc:56152 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity. Involved in dorsal convergence. Predicted to localize to focal adhesion and stress fiber. Is expressed in several structures, including axis; cardiovascular system; digestive system; tail bud; and unfertilized egg. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma).
Genome Resources: Alliance (1),  Gene:573024 (1),  Ensembl(GRCz11):ENSDARG00000023578 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 3 figures (4 images) from Thisse et al., 2004 [MGC:56152]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025473Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26756 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lpp N/A 1
    MO2-lpp N/A 1
    DISEASE ASSOCIATED WITH lpp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid 601626
    Lipoma
    DISEASE ASSOCIATED WITH lpp VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component focal adhesion (more)
    Molecular Function protein binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lpp-201 (1)    Ensembl 6399
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lpp monoclonal Mouse WB BD Biosciences
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lpp No data available
    MARKER RELATIONSHIPS
    lpp Contained in: [BAC] CH211-274B17 (1), DKEY-5E5 (1) (order this), DKEY-13D19 (1) (order this), DKEYP-66B8 (1), DKEYP-111B5 (1)
    lpp Encodes: [EST] fc26e09
    [cDNA] MGC:56152 (1), MGC:192494 (1), MGC:198224 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201198 (1) 2112 nt
    Genomic GenBank:CR382368 (1) 261719 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B7ZV88 (1) 556 aa
    Sequence Information (all 36)
    ORTHOLOGY for lpp ( Chr: 6 )
    CITATIONS (28)