Gene

ephx1

ID
ZDB-GENE-040426-913
Name
epoxide hydrolase 1, microsomal (xenobiotic)
Symbol
ephx1 Nomenclature History
Previous Names
  • zgc:56126
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have cis-stilbene-oxide hydrolase activity. Predicted to be involved in aromatic compound catabolic process and response to toxic substance. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ephx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Hypercholanemia, familial 607748
Associated With ephx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010497 Epoxide hydrolase, N-terminal
Family IPR000639 Epoxide hydrolase-like
Family IPR016292 Epoxide hydrolase
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Epoxide hydrolase Epoxide hydrolase-like Epoxide hydrolase, N-terminal
UniProtKB:F1QC05 456
UniProtKB:Q7ZVB4 456
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations