ZFIN ID: ZDB-GENE-040426-913
Gene Name: epoxide hydrolase 1, microsomal (xenobiotic)
Gene Symbol: ephx1    Nomenclature History

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Previous Name: zgc:56126

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have cis-stilbene-oxide hydrolase activity. Predicted to be involved in aromatic compound catabolic process. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1).
Genome Resources: Alliance (1),  Gene:394043 (1),  Ensembl(GRCz11):ENSDARG00000042854 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7145932]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ephx1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Hypercholanemia, familial 607748
DISEASE ASSOCIATED WITH ephx1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process aromatic compound catabolic process (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function catalytic activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ephx1-201 (1)    Ensembl 2325
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ephx1 No data available
MARKER RELATIONSHIPS
ephx1 Contained in: [BAC] DKEY-5G7 (1) (order this)
ephx1 Encodes: [EST] IMAGE:7145932 (1)
[cDNA] MGC:56126 (1), MGC:192429 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201068 (1) 2121 nt
Genomic GenBank:BX255939 (1) 168897 nt
Select Tool
Polypeptide UniProtKB:F1QC05 (1) 456 aa
Sequence Information (all 13)
ORTHOLOGY for ephx1 ( Chr: 20 )
CITATIONS (25)