ZFIN ID: ZDB-GENE-040426-838
Gene Name: WASH complex subunit 5
Gene Symbol: washc5    Nomenclature History

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Previous Names: spastic paraplegia 8 (1), strumpellin (1), zgc:55908 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Involved in axonogenesis and heart contraction. Predicted to localize to WASH complex. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5).
Genome Resources: Alliance (1),  Gene:393152 (1),  Ensembl(GRCz11):ENSDARG00000101543 (1)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22932 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28731 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-washc5 N/A 1
    MO2-washc5 N/A 1
    DISEASE ASSOCIATED WITH washc5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 8 Alliance Spastic paraplegia 8, autosomal dominant 603563
    Ritscher-Schinzel syndrome 1 Alliance Ritscher-Schinzel syndrome 1 220210
    DISEASE ASSOCIATED WITH washc5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component WASH complex (more)
    Molecular Function molecular_function (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA washc5-201 (1)    Ensembl 3228
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM washc5 No data available
    MARKER RELATIONSHIPS
    washc5 Contained in: [BAC] CH73-386P18 (1), CH211-246D10 (1)
    washc5 Encodes: [cDNA] MGC:55908 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200183 (1) 3758 nt
    Genomic GenBank:CR848685 (1) 149329 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZVM1 (1) 1159 aa
    Sequence Information (all 14)
    ORTHOLOGY for washc5 ( Chr: 16 )
    CITATIONS (20)