Gene

hif1ab

ID
ZDB-GENE-040426-706
Name
hypoxia inducible factor 1 subunit alpha b
Symbol
hif1ab Nomenclature History
Previous Names
  • hif1a (1)
  • HIF1B (1)
  • wu:fb63a10 (1)
  • zgc:55405
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits chromatin binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hematopoietic stem cell differentiation; macrophage migration; and motor neuron axon guidance. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hif1ab Human Ortholog
No data available
Associated With hif1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR013655 PAS fold-3
Domain IPR014887 HIF-1 alpha, transactivation domain, C-terminal
Family IPR001321 Hypoxia-inducible factor-1 alpha
Family IPR021537 Hypoxia-inducible factor, alpha subunit
Homologous_superfamily IPR035965 PAS domain superfamily
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Repeat IPR001610 PAC motif
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily HIF-1 alpha, transactivation domain, C-terminal Hypoxia-inducible factor-1 alpha Hypoxia-inducible factor, alpha subunit Myc-type, basic helix-loop-helix (bHLH) domain PAC motif PAS domain PAS domain superfamily PAS fold-3
UniProtKB:Q6PI33 533
UniProtKB:Q6EHI4 777
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hif1ab polyclonal Rabbit
  • WB
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations