ZFIN ID: ZDB-GENE-040426-706
Gene Name: hypoxia inducible factor 1 subunit alpha b
Gene Symbol: hif1ab    Nomenclature History

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Previous Names: hif1a (1), HIF1B (1), wu:fb63a10 (1), zgc:55405

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits chromatin binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hematopoietic stem cell differentiation; macrophage migration; and motor neuron axon guidance. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in diabetic retinopathy; lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
Genome Resources: Alliance (1),  Gene:393202 (1),  Ensembl(GRCz11):ENSDARG00000034293 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns90 Small Deletion Exon 6 Frameshift, Premature Stop TALEN
f11 Insertion Unknown Unknown ZINC_FINGER_NUCLEASE
f233jy Small Deletion Intron 1 Splice Site TALEN
sa16125 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23673 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29335 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hif1ab
    2
    CRISPR2-hif1ab
    2
    MO1-hif1ab N/A 5
    MO2-hif1ab N/A 5
    MO3-hif1ab N/A 3
    MO4-hif1ab N/A 2
    MO5-hif1ab N/A 1
    TALEN1-hif1ab 2
    TALEN2-hif1ab
    1
    TALEN3-hif1ab 1
    DISEASE ASSOCIATED WITH hif1ab HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hif1ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000014 PAS domain
    Family IPR001321 Hypoxia-inducible factor-1 alpha
    Repeat IPR001610 PAC motif
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Domain IPR013655 PAS fold-3
    Domain IPR014887 HIF-1 alpha, transactivation domain, C-terminal
    Family IPR021537 Hypoxia-inducible factor, alpha subunit
    Homologous_superfamily IPR035965 PAS domain superfamily
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hif1ab-201 (1)    Ensembl 4206
    ncRNA hif1ab-002 (1)    Ensembl 686
    hif1ab-003 (1)    Ensembl 842
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-hif1ab polyclonal Rabbit WB 5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hif1ab
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myl7:LOXP-RFP-LOXP,dnhif1ab) myl7 hif1abRFP Danio rerio 1 2
    Tg(UAS:hif1ab,EGFP) EGFPhif1ab Danio rerio 1 2
    Tg1(UAS:hif1ab,EGFP-CAAX) EGFPhif1ab Danio rerio 1 2
    Tg1(UAS:hif1ab,TagRFP) hif1abTagRFP Danio rerio 1 2
    Tg2(UAS:hif1ab,EGFP-CAAX) EGFPhif1ab Danio rerio 1 2
    Tg2(UAS:hif1ab,TagRFP) hif1abTagRFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    hif1ab Contained in: [BAC] CH211-212G7
    hif1ab Encodes: [EST] fb63a10
    [cDNA] MGC:55405 (1), MGC:192800 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200233 (1) 3387 bp
    Genomic GenBank:BX255914 (1) 217957 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6EHI4 (1) 777 aa
    Sequence Information (all 21)
    ORTHOLOGY for hif1ab ( Chr: 20 )
    CITATIONS (114)