Gene

msh2

ID
ZDB-GENE-040426-2932
Name
mutS homolog 2 (E. coli)
Symbol
msh2 Nomenclature History
Previous Names
  • wu:fc06b02
  • wu:fc13e09
  • zgc:55333
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits guanine/thymine mispair binding activity. Predicted to contribute to DNA binding activity and MutLalpha complex binding activity. Involved in maintenance of DNA repeat elements. Predicted to localize to MutSalpha complex and MutSbeta complex. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); breast cancer; colorectal cancer; and urinary bladder cancer. Is expressed in alar plate midbrain region; immature eye; nervous system; and pharyngeal arch 3-7 skeleton. Orthologous to human MSH2 (mutS homolog 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Feitsma et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With msh2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lynch syndrome 1 Alliance Colorectal cancer, hereditary nonpolyposis, type 1 120435
Muir-Torre syndrome Alliance Muir-Torre syndrome 158320
Mismatch repair cancer syndrome 2 619096
Associated With msh2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000432 DNA mismatch repair protein MutS, C-terminal
Domain IPR007695 DNA mismatch repair protein MutS-like, N-terminal
Domain IPR007696 DNA mismatch repair protein MutS, core
Domain IPR007860 DNA mismatch repair protein MutS, connector domain
Domain IPR007861 DNA mismatch repair protein MutS, clamp
Family IPR011184 DNA mismatch repair Msh2-type
Family IPR032642 DNA mismatch repair protein Msh2
Homologous_superfamily IPR016151 DNA mismatch repair protein MutS, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036187 DNA mismatch repair protein MutS, core domain superfamily
Homologous_superfamily IPR036678 MutS, connector domain superfamily
Domain Details Per Protein
Protein Length DNA mismatch repair Msh2-type DNA mismatch repair protein Msh2 DNA mismatch repair protein MutS, clamp DNA mismatch repair protein MutS, connector domain DNA mismatch repair protein MutS, core DNA mismatch repair protein MutS, core domain superfamily DNA mismatch repair protein MutS, C-terminal DNA mismatch repair protein MutS-like, N-terminal DNA mismatch repair protein MutS, N-terminal MutS, connector domain superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B2GSY7 936
UniProtKB:Q90XA7 936
UniProtKB:Q803R6 936
UniProtKB:F1QEP5 936
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations