ZFIN ID: ZDB-GENE-040426-2924
Gene Name: sestrin 3
Gene Symbol: sesn3    Nomenclature History

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Previous Names: cb261 (1), sb:cb261, wu:fb77c04, wu:fc41d03, wu:fd59d12, zgc:56722

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in locomotory behavior. Predicted to colocalize with the GATOR2 complex; TORC2 complex; and cytoplasm. Is expressed in axis; brain; hypochord; and yolk syncytial layer. Orthologous to human SESN3 (sestrin 3).
Genome Resources: Alliance (1),  Gene:406840 (1),  Ensembl(GRCz11):ENSDARG00000015822 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 3 publications
Directly Submitted Expression Data: 5 figures (6 images) from Thisse et al., 2001 [cb261]
  5 figures (4 images) from Thisse et al., 2004 [IMAGE:7138598]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42597 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sesn3 N/A 1
    MO2-sesn3 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sesn3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sesn3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process locomotory behavior (more)
    Cellular Component nucleus (more)
    Molecular Function leucine binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR006730 Sestrin
    Homologous_superfamily IPR029032 AhpD-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sesn3-201 (1)    Ensembl 3720
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sesn3 No data available
    MARKER RELATIONSHIPS
    sesn3 Contained in: [BAC] CH211-272B8 (1)
    sesn3 Encodes: [EST] cb261 (order this), fb77c04, fc41d03, fd59d12 (1), IMAGE:7138598 (1)
    [cDNA] MGC:56722 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213519 (1) 3752 nt
    Genomic GenBank:CR387932 (1) 152689 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZVJ7 (1) 470 aa
    Sequence Information (all 25)
    ORTHOLOGY for sesn3 ( Chr: 15 )
    CITATIONS (28)