ZFIN ID: ZDB-GENE-040426-2784
Gene Name: SAS-6 centriolar assembly protein
Gene Symbol: sass6    Nomenclature History

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Previous Names: sas-6 (1), cea, cellular atoll, wu:fb98c12 (1), zgc:55668 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Involved in several processes, including embryonic cleavage; microtubule cytoskeleton organization; and spermatogenesis. Localizes to centrosome. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Is expressed in blastomere and unfertilized egg. Orthologous to human SASS6 (SAS-6 centriolar assembly protein).
Genome Resources: Alliance (1),  Gene:406747 (1),  Ensembl(GRCz11):ENSDARG00000058346 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p37mfa Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa5967 Point Mutation Unknown Splice Site ENU
    sa43780 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45755 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sass6 N/A 1
    DISEASE ASSOCIATED WITH sass6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary autosomal recessive microcephaly 14 Alliance ?Microcephaly 14, primary, autosomal recessive 616402
    DISEASE ASSOCIATED WITH sass6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process centrosome duplication (more)
    Cellular Component centrosome (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sass6-201 (1)    Ensembl 3346
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sass6 No data available
    MARKER RELATIONSHIPS
    sass6 Contained in: [BAC] CH211-231A1 (1)
    sass6 Encodes: [EST] fb98c12
    [cDNA] MGC:55668 (1), MGC:193029 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213438 (1) 3169 nt
    Genomic GenBank:BX908398 (1) 118923 nt
    Select Tool
    Polypeptide UniProtKB:B2GRL0 (1) 627 aa
    Sequence Information (all 21)
    ORTHOLOGY for sass6 ( Chr: 22 )
    CITATIONS (30)