ZFIN ID: ZDB-GENE-040426-2761
Gene Name: APEX nuclease (multifunctional DNA repair enzyme) 1
Gene Symbol: apex1
Previous Names: hm:zehn1532, wu:fc13d11, zap1 (1), zgc:66204
Location: Chr: 4 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 10 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66204]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  head, whole organism
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
la024675Tg Transgenic Insertion DNA
sa11621 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-apex1 (1), MO2-apex1 (1), MO3-apex1 (1), MO4-apex1 (1)
    PHENOTYPE
    Data: 6 figures from 2 publications
    Observed in: apoptotic process, blood circulation, brain, cell death (all 12) expand
    DISEASE ASSOCIATED WITH apex1 HUMAN ORTHOLOG No data available
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component cytoplasm (more)
    Molecular Function NOToxidoreductase activity (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004808 (1)
  • InterPro:IPR005135 (1)
  • InterPro:IPR020847 (1)
  • InterPro:IPR020848 (1)
  • PROSITE:PS00726 (1)
  • PROSITE:PS00728 (1)
  • PROSITE:PS51435 (1)
  • Pfam:PF03372 (1)
  • EC:4.2.99.18 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA apex1-001 (1) 2119
    apex1-002 (1) 709
    apex1-003 (1) 388
    apex1-004 (1) 579
    apex1-005 (1) 754
    apex1-006 (1) 682
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-apex1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apex1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    apex1Contained in: [BAC] CH211-214J24 (1) (order this)
    apex1Encodes: [EST] fc13d11, zehn1532 (1)
    [cDNA] MGC:66204 (1) (order this), MGC:113976 (1) (order this), MGC:191415 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213421 (1) 2104bp
    Genomic GenBank:BX323558 (1) 160379bp
    Select Tool
    Polypeptide UniProtKB:A0MTA1 (1) 310aa
    Sequence Clusters UniGene:20170 (1)
    Sequence Information (all 41)
    OTHER apex1 GENE PAGES 
  • Gene:406730 (1)
  • VEGA:OTTDARG00000007616 (1)
  • Ensembl(GRCz10):ENSDARG00000045843 (1)
  • ORTHOLOGY for apex1 (Chr: 4) 
    Species Symbol Chromosome Accession # Evidence
    Human APEX1 14
  • Gene:328
  • OMIM:107748
  • HGNC:587
  • Amino acid sequence comparison (2)
    Download Curated Orthology
    CITATIONS (36)