ZFIN ID: ZDB-GENE-040426-2761
Gene Name: APEX nuclease (multifunctional DNA repair enzyme) 1
Gene Symbol: apex1    Nomenclature History

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Previous Names: hm:zehn1532, wu:fc13d11, zap1 (1), zgc:66204

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; and phosphodiesterase I activity. Involved in several processes, including heart contraction; heart looping; and negative regulation of apoptotic process. Predicted to localize to nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).
Genome Resources: Alliance (1),  Gene:406730 (1),  Ensembl(GRCz11):ENSDARG00000045843 (2)
GENE EXPRESSION
All Expression Data: 14 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66204]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024675Tg Transgenic Insertion Unknown Unknown DNA
sa11621 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-apex1 N/A 1
    MO2-apex1 N/A 1
    MO3-apex1 N/A 1
    MO4-apex1 N/A 4
    DISEASE ASSOCIATED WITH apex1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH apex1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component cytoplasm (more)
    Molecular Function NOT   oxidoreductase activity (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apex1-201 (1)    Ensembl 2119
    apex1-203 (1)    Ensembl 579
    apex1-204 (1)    Ensembl 754
    apex1-205 (1)    Ensembl 388
    apex1-206 (1)    Ensembl 682
    apex1-207 (1)    Ensembl 709
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-apex1 polyclonal Rabbit WB 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apex1 No data available
    MARKER RELATIONSHIPS
    apex1 Contained in: [BAC] CH211-214J24 (1)
    apex1 Encodes: [EST] fc13d11, zehn1532 (1)
    [cDNA] MGC:66204 (1), MGC:113976 (1), MGC:191415 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213421 (1) 2104 nt
    Genomic GenBank:BX323558 (1) 160379 nt
    Select Tool
    Polypeptide UniProtKB:F1QTR9 (1) 341 aa
    Sequence Information (all 44)
    ORTHOLOGY for apex1 ( Chr: 4 )
    CITATIONS (49)