ZFIN ID: ZDB-GENE-040426-2761
Gene Name: APEX nuclease (multifunctional DNA repair enzyme) 1
Gene Symbol: apex1
Previous Names: zap1 (1), hm:zehn1532, wu:fc13d11, zgc:66204
Location: Chr: 4   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 10 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66204]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  head, whole organism
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la024675Tg, sa11621
Knockdown reagents: MO1-apex1 (1), MO2-apex1 (1), MO3-apex1 (1), MO4-apex1 (1)
PHENOTYPE
Data: 6 figures from 2 publications
Observed in: apoptotic process, blood circulation, brain, cell death (all 12) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component cytoplasm (more)
Molecular Function NOT oxidoreductase activity (more)
GO Terms (all 25)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004808 (1)
  • InterPro:IPR005135 (1)
  • InterPro:IPR020847 (1)
  • InterPro:IPR020848 (1)
  • PROSITE:PS00726 (1)
  • PROSITE:PS00728 (1)
  • PROSITE:PS51435 (1)
  • Pfam:PF03372 (1)
  • EC:4.2.99.18 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA apex1-001 (1) 2119
    apex1-002 (1) 709
    apex1-003 (1) 388
    apex1-004 (1) 579
    apex1-005 (1) 754
    apex1-006 (1) 682
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-apex1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apex1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    apex1 Contained in: [BAC] CH211-214J24 (1) (order this)
    apex1 Encodes: [EST] fc13d11, zehn1532 (1)
    [cDNA] MGC:66204 (1) (order this), MGC:113976 (1) (order this), MGC:191415 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213421 (1) 2104 bp
    Genomic GenBank:BX323558 (1) 160379 bp
    Select Tool
    Polypeptide UniProtKB:A0MTA1 (1) 310 aa
    Sequence Clusters UniGene:20170 (1)
    Sequence Information (all 41)
    OTHER apex1 GENE PAGES
  • Gene:406730 (1)
  • VEGA:OTTDARG00000007616 (1)
  • Ensembl(Zv9):ENSDARG00000045843 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish apex1 4  
    Human APEX1 14 (14q11.2)
  • OMIM:107748
  • Gene:328
  • Orthology Details
    CITATIONS (34)