ZFIN ID: ZDB-GENE-040426-2759
Gene Name: mitogen-activated protein kinase kinase 1
Gene Symbol: map2k1    Nomenclature History

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Previous Names: mek1 (1), si:ch211-242m18.2, wu:fj56a12, wu:fj61b01 (1), zgc:56557

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have MAP kinase kinase activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of MAPK activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytoplasm. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 3; malignant glioma; pancreatic adenocarcinoma; renal cell carcinoma; and small intestine adenocarcinoma. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).
Genome Resources: Alliance (1),  Gene:406728 (1),  Ensembl(GRCz11):ENSDARG00000007825 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6511 Point Mutation Unknown Premature Stop ENU
sa43086 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH map2k1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cardiofaciocutaneous syndrome 3 Alliance Cardiofaciocutaneous syndrome 3 615279
    melorheostosis Alliance Melorheostosis, isolated, somatic mosaic 155950
    DISEASE ASSOCIATED WITH map2k1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Molecular Function ATP binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA map2k1-201 (1)    Ensembl 2093
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM map2k1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(hsp70l:dnmap2k1k98m,cryaa:egfp) cryaahsp70l EGFPmap2k1 Danio rerio 1 1
    Tg(hsp70l:map2k1,myl7:EGFP) hsp70lmyl7 EGFPmap2k1 Danio rerio 1 2
    Tg(hsp70l:map2k1_S219D_S223D,myl7:EGFP) hsp70lmyl7 EGFPmap2k1 Danio rerio 1 2
    MARKER RELATIONSHIPS
    map2k1 Contained in: [BAC] CH73-94F11 (1), CH211-242M18 (1)
    map2k1 Encodes: [EST] fj56a12, fj61b01
    [cDNA] MGC:56557 (1), MGC:113988 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213419 (1) 2115 nt
    Genomic GenBank:CT863714 (1) 62423 nt
    Select Tool
    Polypeptide UniProtKB:Q1LUY7 (1) 400 aa
    Sequence Information (all 23)
    ORTHOLOGY for map2k1 ( Chr: 18 )
    CITATIONS (31)