ZFIN ID: ZDB-GENE-040426-2759
Gene Name: mitogen-activated protein kinase kinase 1
Gene Symbol: map2k1
Previous Names: si:ch211-242m18.2, wu:fj56a12, wu:fj61b01 (1), zgc:56557
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. 4 from Nguyen et al., 2011
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43086 Point Mutation Unknown Unknown ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH map2k1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
cardiofaciocutaneous syndrome Cardiofaciocutaneous syndrome 3 615279
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA map2k1-001 (1) 2093
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM map2k1
    Tg(hsp70l:map2k1,myl7:EGFP), Tg(hsp70l:map2k1_S219D_S223D,myl7:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    map2k1Contained in: [BAC] CH73-94F11 (1) (order this), CH211-242M18 (1) (order this)
    map2k1Encodes: [EST] fj56a12, fj61b01
    [cDNA] MGC:56557 (1) (order this), MGC:113988 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213419 (1) 2115bp
    Genomic GenBank:CT863714 (1) 62423bp
    Select Tool
    Polypeptide UniProtKB:Q1LUY7 (1) 400aa
    Sequence Clusters UniGene:107100 (1)
    Sequence Information (all 23)
    OTHER map2k1 GENE PAGES
  • Gene:406728 (1)
  • VEGA:OTTDARG00000023382 (1)
  • Ensembl(GRCz10):ENSDARG00000007825 (1)
  • ORTHOLOGY for map2k1 (Chr: 18)
    Species Symbol Chromosome Accession # Evidence
    Human MAP2K1 15
  • Gene:5604
  • OMIM:176872
  • HGNC:6840
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Phylogenetic tree (1)
    Mouse Map2k1 9
  • MGI:1346866
  • Gene:26395
  • Phylogenetic tree (1)
    Download Curated Orthology
    CITATIONS (24)