ZFIN ID: ZDB-GENE-040426-2759
Gene Name: mitogen-activated protein kinase kinase 1
Gene Symbol: map2k1
Previous Names: si:ch211-242m18.2, wu:fj56a12, wu:fj61b01 (1), zgc:56557
Location: Chr: 18   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. 4 from Nguyen et al., 2011
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH map2k1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
cardiofaciocutaneous syndrome Cardiofaciocutaneous syndrome 3 615279
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component intracellular (more)
Molecular Function ATP binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR002290 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA map2k1-001 (1) 2093
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM map2k1
    Tg(hsp70l:map2k1,myl7:EGFP), Tg(hsp70l:map2k1_S219D_S223D,myl7:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    map2k1 Contained in: [BAC] CH73-94F11 (1) (order this), CH211-242M18 (1) (order this)
    map2k1 Encodes: [EST] fj56a12, fj61b01
    [cDNA] MGC:56557 (1) (order this), MGC:113988 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213419 (1) 2115 bp
    Genomic GenBank:CT863714 (1) 62423 bp
    Select Tool
    Polypeptide UniProtKB:Q1LUY7 (1) 400 aa
    Sequence Clusters UniGene:107100 (1)
    Sequence Information (all 23)
    OTHER map2k1 GENE PAGES
  • Gene:406728 (1)
  • VEGA:OTTDARG00000023382 (1)
  • Ensembl(Zv9):ENSDARG00000007825 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish map2k1 18  
    Human MAP2K1 15 (15q22.1-q22.33)
  • OMIM:176872
  • Gene:5604
  • Orthology Details
    CITATIONS (20)