ZFIN ID: ZDB-GENE-040426-2734
Gene Name: protein inhibitor of activated STAT, 4a
Gene Symbol: pias4a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: pias4, piasy (1), wu:fc54c11 (1), wu:fi18c10, wu:fi20e09, wu:fk93f11, zgc:66410

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II transcription factor binding activity; SUMO ligase activity; and transcription coregulator activity. Involved in negative regulation of type I interferon production and negative regulation of type I interferon-mediated signaling pathway. Localizes to nucleus. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4).
Genome Resources: Alliance (1),  Gene:406712 (1),  Ensembl(GRCz11):ENSDARG00000007081 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7162672]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18392 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24157 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pias4a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pias4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pias4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of type I interferon-mediated signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pias4a-201 (1)    Ensembl 4101
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pias4a No data available
    MARKER RELATIONSHIPS
    pias4a Contained in: [BAC] CH211-195M2 (1)
    pias4a Contains: [SNP] rs3729302 (1)
    pias4a Encodes: [EST] fc54c11, fi18c10 (1), fi20e09 (1), fk93f11 (1), IMAGE:7162672 (1)
    [cDNA] MGC:66410 (1), MGC:85850 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213403 (1) 3681 nt
    Genomic GenBank:BX088720 (1) 190269 nt
    Select Tool
    Polypeptide UniProtKB:A0A452GCC0 (1) 508 aa
    Sequence Information (all 27)
    ORTHOLOGY for pias4a ( Chr: 22 )
    CITATIONS (26)