ZFIN ID: ZDB-GENE-040426-2596
Gene Name: protein kinase C and casein kinase substrate in neurons 2
Gene Symbol: pacsin2    Nomenclature History

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Previous Name: zgc:77519

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have cytoskeletal protein binding activity and phospholipid binding activity. Predicted to be involved in cytoskeleton organization and plasma membrane tubulation. Predicted to localize to the cytoplasm; cytoskeleton; and plasma membrane. Is expressed in several structures, including anterior axial hypoblast; axial mesoderm; axis; hatching gland; and notochord. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2).
Genome Resources: Alliance (1),  Gene:404601 (1),  Ensembl(GRCz11):ENSDARG00000078014 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [MGC:77519]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13662 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16198 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20325 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pacsin1b,pacsin2
    1
    CRISPR1-pacsin2
    1
    DISEASE ASSOCIATED WITH pacsin2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pacsin2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component cytoplasm (more)
    Molecular Function kinase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001060 FCH domain
    Domain IPR001452 SH3 domain
    Homologous_superfamily IPR027267 AH/BAR domain superfamily
    Family IPR028521 Protein kinase C and casein kinase substrate in neurons protein 2
    Domain IPR031160 F-BAR domain
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Domain IPR037453 PACSIN2, F-BAR domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pacsin2-201 (1)    Ensembl 2327
    pacsin2-202 (1)    Ensembl 619
    pacsin2-203 (1)    Ensembl 578
    ncRNA pacsin2-002 (1)    Ensembl 372
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pacsin2 No data available
    MARKER RELATIONSHIPS
    pacsin2 Contained in: [Fosmid] CH1073-378E14 (1), ZFOS-2131B9 (1)
    pacsin2 Encodes: [cDNA] MGC:77519 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207069 (1) 2223 bp
    Genomic GenBank:CU695158 (1) 39399 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IHF0 (1) 491 aa
    Sequence Information (all 20)
    ORTHOLOGY for pacsin2 ( Chr: 4 )
    CITATIONS (21)