ZFIN ID: ZDB-GENE-040426-2435
Gene Name: LEO1 homolog, Paf1/RNA polymerase II complex component
Gene Symbol: leo1    Nomenclature History

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Previous Name: zgc:77374

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in several processes, including animal organ development; melanocyte differentiation; and xanthophore differentiation. Localizes to Cdc73/Paf1 complex. Is expressed in brain; eye; immature eye; pharyngeal arch; and somite. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component).
Genome Resources: Alliance (1),  Gene:404599 (1),  Ensembl(GRCz11):ENSDARG00000055357 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:77374]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
knu6 Point Mutation Unknown Premature Stop ENU
la1186 Point Mutation Unknown Premature Stop ENU
sa2979 Point Mutation Unknown Premature Stop ENU
sa29073 Point Mutation Unknown Premature Stop ENU
sa43155 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44895 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-leo1 N/A 1
    DISEASE ASSOCIATED WITH leo1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH leo1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic cranial skeleton morphogenesis (more)
    Cellular Component Cdc73/Paf1 complex (more)
    Molecular Function RNA polymerase II C-terminal domain phosphoserine binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA leo1-201 (1)    Ensembl 2284
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM leo1 No data available
    MARKER RELATIONSHIPS
    leo1 Contained in: [BAC] DKEY-7C4 (1) (order this), DKEY-14B24 (1) (order this)
    leo1 Encodes: [cDNA] MGC:77374 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_207067 (1) 2323 nt
    Genomic GenBank:CR848839 (1) 101830 nt
    Select Tool
    Polypeptide UniProtKB:Q6NYV9 (1) 696 aa
    Sequence Information (all 11)
    ORTHOLOGY for leo1 ( Chr: 18 )
    CITATIONS (29)