Gene

spast

ID
ZDB-GENE-040426-2331
Name
spastin
Symbol
spast Nomenclature History
Previous Names
  • spg4 (1)
  • zgc:85952
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have microtubule-severing ATPase activity and tubulin binding activity. Involved in several processes, including axonogenesis; cytoplasmic microtubule organization; and positive regulation of cellular component organization. Predicted to localize to microtubule cytoskeleton; midbody; and nuclear membrane. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spast Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 4 Alliance Spastic paraplegia 4, autosomal dominant 182601
Associated With spast Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003960 ATPase, AAA-type, conserved site
Domain IPR003593 AAA+ ATPase domain
Domain IPR003959 ATPase, AAA-type, core
Domain IPR007330 MIT
Domain IPR015415 Vps4 oligomerisation, C-terminal
Domain IPR041569 AAA ATPase, AAA+ lid domain
Family IPR017179 Spastin
Family IPR035106 Spastin, chordate
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA ATPase, AAA+ lid domain AAA+ ATPase domain ATPase, AAA-type, conserved site ATPase, AAA-type, core MIT P-loop containing nucleoside triphosphate hydrolase Spastin Spastin, chordate Vps4 oligomerisation, C-terminal
UniProtKB:Q6NW58 570
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-spast polyclonal Rabbit
  • WB
2
Ab2-spast polyclonal Rabbit
Millipore
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations