ZFIN ID: ZDB-GENE-040426-2331
Gene Name: spastin
Gene Symbol: spast
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: spg4 (1), zgc:85952

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have microtubule-severing ATPase activity and tubulin binding activity; involved in several processes, including cytoplasmic microtubule organization, endosome organization, and nervous  ...
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85952]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19591 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko988a Small Deletion Unknown Unknown CRISPR
    zko988b Indel Unknown Unknown CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 8 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH spast HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 4 Spastic paraplegia 4, autosomal dominant 182601
    DISEASE ASSOCIATED WITH spast VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hereditary spastic paraplegia WT + MO3-spast standard conditions Julien et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    Cellular Component COLOCALIZES_WITH microtubule cytoskeleton (more)
    Molecular Function alpha-tubulin binding (more)
    GO Terms (all 48)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003593 (1)
  • InterPro:IPR003959 (1)
  • InterPro:IPR003960 (1)
  • InterPro:IPR007330 (1)
  • InterPro:IPR015415 (1)
  • InterPro:IPR017179 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR035106 (1)
  • PROSITE:PS00674 (1)
  • Pfam:PF00004 (1)
  • Pfam:PF09336 (1)
  • EC:5.6.1.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA spast-001 (1) 2413
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM spast No data available
    MARKER RELATIONSHIPS
    spastContained in: [BAC] CH73-233A22 (1) (order this)
    spastEncodes: [cDNA] MGC:85952 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212915 (1) 2338bp
    Genomic GenBank:CU651563 (1) 99177bp
    Select Tool
    Polypeptide UniProtKB:Q6NW58 (1) 570aa
    Sequence Clusters UniGene:30307 (1)
    Sequence Information (all 16)
    OTHER spast GENE PAGES
  • Alliance (1)
  • Gene:405851 (1)
  • VEGA:OTTDARG00000029983 (1)
  • Ensembl(GRCz11):ENSDARG00000024933 (2)
  • ORTHOLOGY for spast (Chr: 1)
    CITATIONS (31)