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Gene

spint1a

ID
ZDB-GENE-040426-2169
Name
serine peptidase inhibitor, Kunitz type 1 a
Symbol
spint1a Nomenclature History
Previous Names
  • hai1a (1)
  • spint1l
  • cb376 (1)
  • sb:cb376
  • serine protease inhibitor HGFAI (1)
  • zgc:64075
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables peptidase inhibitor activity. Acts upstream of or within several processes, including collagen fibril organization; epidermis development; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including apical ectodermal ridge; digestive system; fin fold pectoral fin bud; periderm; and sensory system. Used to study psoriasis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
35 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spint1a Human Ortholog
No data available
Associated With spint1a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000601 PKD domain
Domain IPR002223 Pancreatic trypsin inhibitor Kunitz domain
Domain IPR011106 Seven cysteines, N-terminal
Domain IPR013980 MANSC domain
Domain IPR022409 PKD/Chitinase domain
Family IPR042482 Kunitz-type protease inhibitor 1
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR035986 PKD domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Immunoglobulin-like fold Kunitz-type protease inhibitor 1 LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat MANSC domain Pancreatic trypsin inhibitor Kunitz domain Pancreatic trypsin inhibitor Kunitz domain superfamily PKD/Chitinase domain PKD domain PKD domain superfamily Proteinase inhibitor I2, Kunitz, conserved site Seven cysteines, N-terminal
UniProtKB:A0A0G2KUL6 515
UniProtKB:A0A2R8QCE4 523
UniProtKB:A9JT55 516
UniProtKB:Q7T363 516
UniProtKB:Q6DRJ1 515
UniProtKB:A7YYI0 510
UniProtKB:A0A2R8QMJ2 498
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations