ZFIN ID: ZDB-GENE-040426-2169
Gene Name: serine peptidase inhibitor, Kunitz type 1 a
Gene Symbol: spint1a    Nomenclature History

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Previous Names: hai1a (1), spint1l, cb376 (1), sb:cb376, serine protease inhibitor HGFAI (1), zgc:64075

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits peptidase inhibitor activity. Involved in several processes, including collagen fibril organization; epidermis development; and neutrophil chemotaxis. Predicted to localize to integral component of membrane. Is expressed in several structures, including apical ectodermal ridge; digestive system; fin fold pectoral fin bud; periderm; and sensory system. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).
Genome Resources: Alliance (1),  Gene:406426 (1),  Ensembl(GRCz11):ENSDARG00000102332 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fr26 Point Mutation Unknown Unknown ENU
hi2217Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sfc19 Insertion Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-spint1a N/A 4
    MO2-spint1a N/A 2
    DISEASE ASSOCIATED WITH spint1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH spint1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process collagen fibril organization (more)
    Cellular Component integral component of membrane (more)
    Molecular Function serine-type endopeptidase inhibitor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spint1a No data available
    MARKER RELATIONSHIPS
    spint1a Encodes: [EST] cb376 (1) (order this)
    [cDNA] MGC:64075 (1), MGC:174059 (1), MGC:174532 (1), MGC:192478 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213152 (1)
    Genomic GenBank:CABZ01062996 (1) 19971 nt
    Polypeptide UniProtKB:A0A2R8QCE4 (1) 523 aa
    Sequence Information (all 38)
    ORTHOLOGY for spint1a ( Chr: 17 )
    CITATIONS (30)