ZFIN ID: ZDB-GENE-040426-2069
Gene Name: engulfment and cell motility 1 (ced-12 homolog, C. elegans)
Gene Symbol: elmo1    Nomenclature History

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Previous Names: im:7151147, wu:fq24e08, zgc:85612 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have Rac GTPase binding activity. Involved in cilium assembly; lymphangiogenesis; and positive regulation of angiogenesis. Predicted to localize to guanyl-nucleotide exchange factor complex and plasma membrane. Is expressed in several structures, including blood vessel; immature eye; mesoderm; nervous system; and pronephric tubule. Orthologous to human ELMO1 (engulfment and cell motility 1).
Genome Resources: Alliance (1),  Gene:406364 (1),  Ensembl(GRCz11):ENSDARG00000098753 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028049Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028050Tg Transgenic Insertion Unknown Unknown DNA
    sa23561 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23562 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um92 Indel Unknown Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-elmo1
    1
    MO1-elmo1 N/A 3
    MO2-elmo1 N/A 3
    TALEN1-elmo1
    2
    DISEASE ASSOCIATED WITH elmo1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH elmo1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component guanyl-nucleotide exchange factor complex (more)
    Molecular Function Rac GTPase binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA elmo1-202 (1)    Ensembl 784
    elmo1-205 (1)    Ensembl 3398
    ncRNA elmo1-002 (1) 962
    elmo1-004 (1) 310
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-elmo1 polyclonal Goat WB Everest Biotech
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM elmo1 No data available
    MARKER RELATIONSHIPS
    elmo1 Contained in: [BAC] CH73-302O18 (1), DKEY-125F15 (1) (order this)
    [Fosmid] CH1073-283J24 (1)
    elmo1 Encodes: [EST] fq24e08 (1) (order this), IMAGE:7147174 (1), IMAGE:7151147 (1)
    [cDNA] MGC:85612 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213091 (1) 3396 nt
    Genomic GenBank:CU928445 (1) 161714 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IHP8 (1) 740 aa
    Sequence Information (all 32)
    ORTHOLOGY for elmo1 ( Chr: 19 )
    CITATIONS (38)