Gene

dusp1

ID
ZDB-GENE-040426-2018
Name
dual specificity phosphatase 1
Symbol
dusp1 Nomenclature History
Previous Names
  • mkp-1 (1)
  • cb269 (1)
  • id:ibd2586
  • sb:cb269
  • wu:fd19g02
  • wu:fe50g09
  • zgc:55920
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of MAPK cascade; and protein dephosphorylation. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including forebrain neural keel; margin; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
Genome Resources
Note
None
Expression
All Expression Data
24 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dusp1 Human Ortholog
No data available
Associated With dusp1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000387 Tyrosine specific protein phosphatases domain
Domain IPR001763 Rhodanese-like domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR020422 Dual specificity protein phosphatase domain
Family IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR036873 Rhodanese-like domain superfamily
Domain Details Per Protein
Protein Length Dual specificity protein phosphatase domain Mitogen-activated protein (MAP) kinase phosphatase Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Rhodanese-like domain Rhodanese-like domain superfamily Tyrosine specific protein phosphatases domain
UniProtKB:Q6IQU5 360
UniProtKB:Q7ZVL8 360
UniProtKB:A0A0R4IS50 369
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations