ZFIN ID: ZDB-GENE-040426-2018
Gene Name: dual specificity phosphatase 1
Gene Symbol: dusp1    Nomenclature History

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Previous Names: mkp-1 (1), cb269 (1), id:ibd2586, sb:cb269, wu:fd19g02, wu:fe50g09, zgc:55920

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of MAPK cascade; and protein dephosphorylation. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including forebrain neural keel; mesoderm; nervous system; neural tube; and tail bud. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
Genome Resources: Alliance (1),  Gene:406340 (1),  Ensembl(GRCz11):ENSDARG00000100515 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13958 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dusp1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dusp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dephosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dusp1-202 (1)    Ensembl 2326
    ncRNA dusp1-002 (1)    Ensembl 545
    dusp1-003 (1)    Ensembl 715
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dusp1 No data available
    MARKER RELATIONSHIPS
    dusp1 Contained in: [BAC] CH211-198F4 (1)
    dusp1 Encodes: [EST] cb269 (1) (order this), fb18e05 (1) (order this), fd19g02 (1), fe50g09 (1), ibd2586 (1)
    [cDNA] MGC:55920 (1), MGC:86606 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213067 (1) 2318 nt
    Genomic GenBank:CR381700 (1) 203630 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IS50 (1) 369 aa
    Sequence Information (all 21)
    ORTHOLOGY for dusp1 ( Chr: 14 )
    CITATIONS (34)