ZFIN ID: ZDB-GENE-040426-1975
Gene Name: growth factor receptor-bound protein 2b
Gene Symbol: grb2b
Sequence Ontology ID : SO:0000704

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Previous Names: grb2, fb18e12, wu:fb18e12, wu:fb34e06, zgc:73077

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(Including Attributions)
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to be involved in Ras protein signal transduction; orthologous to human GRB2 (growth factor receptor bound protein 2).
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 5 figures (5 images) from Thisse et al., 2004 [MGC:73077]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011780Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015143Tg Transgenic Insertion Unknown Unknown DNA
    la015144Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024047Tg Transgenic Insertion Unknown Unknown DNA
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH grb2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH grb2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Ras protein signal transduction (more)
    Cellular Component extrinsic component of cytoplasmic side of plasma membrane (more)
    Molecular Function non-membrane spanning protein tyrosine kinase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000980 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR030219 (1)
  • InterPro:IPR035641 (1)
  • InterPro:IPR035643 (1)
  • InterPro:IPR036028 (1)
  • InterPro:IPR036860 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50002 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF00018 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA grb2b-202 (1) 777
    grb2b-203 (1) 1490
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM grb2b No data available
    MARKER RELATIONSHIPS
    grb2bContained in: [BAC] DKEY-164P3 (1) (order this)
    grb2bEncodes: [EST] fb18e12, fb34e06 (1)
    [cDNA] MGC:73077 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213035 (1) 1230bp
    Genomic GenBank:BX465842 (1) 194224bp
    Select Tool
    Polypeptide UniProtKB:Q6PC73 (1) 217aa
    Sequence Clusters UniGene:114331 (1)
    Sequence Information (all 24)
    OTHER grb2b GENE PAGES
  • Alliance (1)
  • Gene:406308 (1)
  • VEGA:OTTDARG00000019850 (1)
  • Ensembl(GRCz11):ENSDARG00000038059 (2)
  • ORTHOLOGY for grb2b (Chr: 3)
    CITATIONS (24)