ZFIN ID: ZDB-GENE-040426-1753
Gene Name: coiled-coil-helix-coiled-coil-helix domain containing 10
Gene Symbol: chchd10    Nomenclature History

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Previous Names: chchd2, zgc:73308

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Involved in axonogenesis and skeletal myofibril assembly. Predicted to localize to mitochondrion and nucleus. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and optic vesicle. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10).
Genome Resources: Alliance (1),  Gene:393757 (1),  Ensembl(GRCz11):ENSDARG00000010717 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18461 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chchd10 N/A 1
    MO2-chchd10 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chchd10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    frontotemporal dementia and/or amyotrophic lateral sclerosis-2 Alliance Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 615911
    Spinal muscular atrophy, Jokela type 615048
    ?Myopathy, isolated mitochondrial, autosomal dominant 616209
    DISEASE ASSOCIATED WITH chchd10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component mitochondrion (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chchd10-201 (1)    Ensembl 781
    chchd10-202 (1)    Ensembl 452
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chchd10 No data available
    MARKER RELATIONSHIPS
    chchd10 Contained in: [BAC] DKEYP-87D8 (1)
    chchd10 Encodes: [cDNA] MGC:73308 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200784 (1) 701 nt
    Genomic GenBank:CR847785 (1) 166647 nt
    Select Tool
    Polypeptide UniProtKB:Q6PBP6 (1) 143 aa
    Sequence Information (all 9)
    ORTHOLOGY for chchd10 ( Chr: 21 )
    CITATIONS (18)