ZFIN ID: ZDB-GENE-040426-1648
Gene Name: N-myc downstream regulated 1b
Gene Symbol: ndrg1b    Nomenclature History

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Previous Names: ndrg1l, zgc:73047

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Involved in regulation of T cell differentiation and thymus development. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Is expressed in epiphysis; optic vesicle; pro-T cell; retina; and thymus. Orthologous to human NDRG1 (N-myc downstream regulated 1).
Genome Resources: Alliance (1),  Gene:393665 (1),  Ensembl(GRCz11):ENSDARG00000010420 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 5 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [MGC:73047]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2849 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ndrg1b N/A 1
    PHENOTYPE
    Data: Fig. 5 from Li et al., 2016
    Observed in:
    DISEASE ASSOCIATED WITH ndrg1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 4D Alliance Charcot-Marie-Tooth disease, type 4D 601455
    DISEASE ASSOCIATED WITH ndrg1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of T cell differentiation (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR004142 NDRG
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    Family IPR030693 Protein NDRG1
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ndrg1b-201 (1)    Ensembl 1778
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ndrg1b Mouse IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ndrg1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(rho:ndrg1b-IRES-mSEGFP-CAAX) rho CAAXGFPIRESndrg1b Danio rerio 1 1
    MARKER RELATIONSHIPS
    ndrg1b Contained in: [BAC] DKEY-97I18 (1) (order this)
    ndrg1b Encodes: [cDNA] MGC:73047 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200692 (1) 1711 bp
    Genomic GenBank:CR855311 (1) 161379 bp
    Select Tool
    Polypeptide UniProtKB:A0A146JRF4 (1) 359 aa
    Sequence Clusters UniGene:8090 (1)
    Sequence Information (all 19)
    ORTHOLOGY for ndrg1b ( Chr: 16 )
    CITATIONS (27)