timm50

ID

ZDB-GENE-040426-1618

Name

translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)

Symbol

timm50 Nomenclature History

Previous Names

zgc:66357 (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Acts upstream of or within apoptotic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in several structures, including immature eye; margin; midbrain; pectoral fin musculature; and segmental plate. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66357 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With timm50 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
3-methylglutaconic aciduria type 9	Alliance	3-methylglutaconic aciduria, type IX	617698

Associated With timm50 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004274	FCP1 homology domain
Family	IPR050365	Mitochondrial import inner membrane translocase subunit TIM50
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR036412	HAD-like superfamily