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ZIRC
ZFIN ID: ZDB-GENE-040426-1600
Gene Name: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Gene Symbol: mlh1
Sequence Ontology ID : SO:0000704

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Previous Name: zgc:66301 (1)

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ATPase activity. Involved in meiosis I and spermatogenesis. Predicted to localize to the MutLalpha complex and chiasma. Human ortholog(s) of this gene implicated in Lynch syndrome;  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66301]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
DISEASE ASSOCIATED WITH mlh1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
hereditary nonpolyposis colorectal cancer type 2 Colorectal cancer, hereditary nonpolyposis, type 2 609310
Muir-Torre syndrome Muir-Torre syndrome 158320
Mismatch repair cancer syndrome 276300
DISEASE ASSOCIATED WITH mlh1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chiasma assembly (more)
Cellular Component mismatch repair complex (more)
Molecular Function ATPase activity (more)
GO Terms (all 15)
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA mlh1-201 (1) 2318
mlh1-202 (1) 778
GENE PRODUCT DESCRIPTION No description available
INTERACTIONS AND PATHWAYS
ANTIBODIESNo data available
PLASMIDSNo data available
CONSTRUCTS WITH SEQUENCES FROM mlh1 No data available
MARKER RELATIONSHIPS
mlh1Contained in: [BAC] CH211-229O17 (1) (order this)
mlh1Encodes: [cDNA] MGC:66301 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_200659 (1) 2407bp
Genomic GenBank:BX936318 (1) 158912bp
Select Tool
Polypeptide UniProtKB:B8A6F5 (1) 725aa
Sequence Clusters UniGene:77529 (1)
Sequence Information (all 14)
ORTHOLOGY for mlh1 (Chr: 13)
CITATIONS (31)