ZFIN ID: ZDB-GENE-040426-1600
Gene Name: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Gene Symbol: mlh1
Sequence Ontology ID : SO:0000704

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Previous Name: zgc:66301 (1)

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66301]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 11 figures from 3 publications
Observed in:
DISEASE ASSOCIATED WITH mlh1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
hereditary nonpolyposis colorectal cancer type 2 Colorectal cancer, hereditary nonpolyposis, type 2 609310
Lynch syndrome Colorectal cancer, hereditary nonpolyposis, type 2 609310
Muir-Torre syndrome Muir-Torre syndrome 158320
Mismatch repair cancer syndrome 276300
DISEASE ASSOCIATED WITH mlh1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chiasma assembly (more)
Cellular Component mismatch repair complex (more)
Molecular Function ATPase activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002099 (1)
  • InterPro:IPR003594 (1)
  • InterPro:IPR011186 (1)
  • InterPro:IPR013507 (1)
  • InterPro:IPR014721 (1)
  • InterPro:IPR014762 (1)
  • InterPro:IPR020568 (1)
  • InterPro:IPR032189 (1)
  • InterPro:IPR036890 (1)
  • InterPro:IPR038973 (1)
  • PROSITE:PS00058 (1)
  • Pfam:PF01119 (1)
  • Pfam:PF16413 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mlh1-001 (1) 2318
    mlh1-002 (1) 778
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mlh1 No data available
    MARKER RELATIONSHIPS
    mlh1Contained in: [BAC] CH211-229O17 (1) (order this)
    mlh1Encodes: [cDNA] MGC:66301 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200659 (1) 2407bp
    Genomic GenBank:BX936318 (1) 158912bp
    Select Tool
    Polypeptide UniProtKB:B8A6F5 (1) 725aa
    Sequence Clusters UniGene:77529 (1)
    Sequence Information (all 14)
    OTHER mlh1 GENE PAGES
  • Alliance (1)
  • Gene:393632 (1)
  • VEGA:OTTDARG00000020917 (1)
  • Ensembl(GRCz11):ENSDARG00000025948 (1)
  • ORTHOLOGY for mlh1 (Chr: 13)
    CITATIONS (30)