ZFIN ID: ZDB-GENE-040426-1446
Gene Name: iroquois homeobox 2a
Gene Symbol: irx2a    Nomenclature History

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Previous Names: ziro2a (1), zgc:65872 (1), zgc:77209

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in retina morphogenesis in camera-type eye. Predicted to localize to the nucleus. Is expressed in several structures, including basal plate midbrain region; nervous system; neural rod; otic vesicle; and pectoral fin bud. Orthologous to human IRX2 (iroquois homeobox 2).
Genome Resources: Alliance (1),  Gene:394032 (1),  Ensembl(GRCz11):ENSDARG00000001785 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10776 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17696 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19128 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22736 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-irx2a N/A 1
    MO2-irx2a N/A 2
    DISEASE ASSOCIATED WITH irx2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH irx2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephric nephron tubule epithelial cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Domain IPR003893 Iroquois-class homeodomain protein
    Domain IPR008422 Homeobox KN domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irx2a-201 (1)    Ensembl 2295
    irx2a-202 (1)    Ensembl 499
    ncRNA irx2a-002 (1)    Ensembl 968
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irx2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-irx2a-LOXP-gata2a:EGFP-5HS4) gata2airx2a DsRedEGFP Danio rerioXenopus laevis 3 3
    Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-irx2a-LOXP-gata2a:EGFP-5HS4) gata2airx2a DsRedEGFP Danio rerioXenopus laevis 3 3
    MARKER RELATIONSHIPS
    irx2a Contained in: [Fosmid] ZFOS-267C11 (1), ZFOS-1179H2 (1)
    irx2a Contains: [SSLP] z7233 (1)
    irx2a Encodes: [EST] eu2449 (1)
    [cDNA] MGC:65872 (1), MGC:77209 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201057 (1) 2239 bp
    Genomic GenBank:CU658470 (1) 45186 bp
    Select Tool
    Polypeptide UniProtKB:Q5I8Y1 (1) 432 aa
    Sequence Information (all 25)
    ORTHOLOGY for irx2a ( Chr: 16 )
    CITATIONS (29)