Gene

irx2a

ID
ZDB-GENE-040426-1446
Name
iroquois homeobox 2a
Symbol
irx2a Nomenclature History
Previous Names
  • ziro2a (1)
  • zgc:65872 (1)
  • zgc:77209
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within pronephric nephron tubule epithelial cell differentiation and retina morphogenesis in camera-type eye. Is expressed in several structures, including basal plate midbrain region; nervous system; otic vesicle; pectoral fin bud; and pronephric tubule. Orthologous to human IRX2 (iroquois homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irx2a Human Ortholog
No data available
Associated With irx2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003893 Iroquois-class homeodomain protein
Domain IPR008422 Homeobox KN domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox KN domain Homeobox-like domain superfamily Iroquois-class homeodomain protein
UniProtKB:Q5I8Y1 432
UniProtKB:F8W4X2 101
UniProtKB:Q7SZP0 432
UniProtKB:Q6P0B6 432
UniProtKB:A0A2R8RSU7 418
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations